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DNA Repair and Replication Mechanisms and Clinical Significance

DNA Repair and Replication Mechanisms and Clinical Significance

DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease with particular focus on both the causes and treatments which make use of DNA Damage Repair (DDR) pathways. Key Selling Features: Chapters written by leading researchers Includes description of replication processes causes of damage and methods of repair | DNA Repair and Replication Mechanisms and Clinical Significance

GBP 77.99
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The Repair of Vehicle Bodies

The Repair of Vehicle Bodies

The revised and updated seventh edition of this best-selling reference manual on vehicle body repair brings the book up to date for the current body repair trade. It serves as a comprehensive guide covering the vocationally related qualification (VRQ) required by the modern student and apprentice as well as providing the CPD essential for all working professionals. The entire book is overhauled to reflect current industry trends with regards to materials processes and procedures. New additions include: An entirely new section on the work of the MET technician (mechanical electrical and trim) New developments in body repair methodology such as repair pods and the greater use of alignment equipment Greater emphasis on the environment with new sections on hybrid vehicles and the hazards of starting current vehicles with high levels of technology Details on both the historic and the current joining methods for the vintage and modern markets Full coverage on the legalities surrounding insurance work for bodyshop staff Updated tables and illustrations This book not only provides the knowledge and skills for body repair it helps to develop a real understanding of the how and why behind this information. It will be essential for anyone studying Levels 1-3 Vehicle Body Repair Vehicle Refinishing and MET courses including the new apprenticeships and technical certificates from the IMI Pearson-BTEC and C&G. HNC and degree Automotive Engineering students will find the text valuable to develop skills and knowledge for practical project work. Industry professionals vehicle restorers and car DIY enthusiasts will continue to find it an essential and comprehensive source of information. | The Repair of Vehicle Bodies

GBP 46.99
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Doors History Repair and Conservation

Doors History Repair and Conservation

In Doors: History Repair and Conservation readers are guided through the function history development care repair and conservation of doors by chapter authors who are experts in their field. This book offers depth and range of detail from dating and archaeology right through to the surveying recording engineering and curation of the door its furniture and the part of the building into which it is set. Doors vary from basic designs to exceptional and intricate masterpieces of craftmanship. Whether wood stone metal or glass throughout history doors have been vital barriers against weather and intruders providing those inside with protection privacy and comfort. Split into three sections this book covers history development identification and dating of doors maintenance and engineering of doors and door openings and materials of doors their furniture openings and surrounds. Throughout the book the authors provide detailed photographs drawings techniques and methodologies and the latest research available. Doors is the first major reference work devoted to the understanding of doors and doorways and the issues surrounding their repair and conservation. This comprehensive highly-illustrated full-colour study will provide professionals students and academics with a complete overview of door conservation that will inform both research and practice for years to come. | Doors History Repair and Conservation

GBP 77.99
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Repair of Concrete Structures to EN 1504

Repair of Concrete Structures to EN 1504

Originally published by the Danish Standards Institute this guide to the EN 1504 standards addresses the principles methods and the choice of repair materials and systems for the rehabilitation of damaged concrete structures. The standards not only provide a common set of values for the industry but also support the improvement of supply chain integration and specialist inputs in the early design stages of projects where this can be most beneficial. The book gives practical guidelines to the main principles of the EN 1504 standards along with worked examples. It also gives concise explanatory notes to the annexes which will help any building and construction professional fulfill the requirements for repairing concrete. | Repair of Concrete Structures to EN 1504

GBP 59.99
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Small Animal Fracture Repair A Case-Based Approach

Small Animal Fracture Repair A Case-Based Approach

This book provides students practitioners residents and surgeons with an easily accessible and visual guide to successful methods of repairing more common fractures of dogs and cats. The concept allows clinicians to easily compare a fracture of a patient presented to them to the book and see what successful repairs were performed. There is also dialogue on the treatment options and special considerations. Importantly follow-up radiographs provide insight into what type and rate of healing is to be expected. | Small Animal Fracture Repair A Case-Based Approach

GBP 44.99
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FRP Composites for Reinforced and Prestressed Concrete Structures A Guide to Fundamentals and Design for Repair and Retrofit

FRP Composites for Reinforced and Prestressed Concrete Structures A Guide to Fundamentals and Design for Repair and Retrofit

High strength fibre composites (FRPs) have been used with civil structures since the 1980s mostly in the repair strengthening and retrofitting of concrete structures. This has attracted considerable research and the industry has expanded exponentially in the last decade. Design guidelines have been developed by professional organizations in a number of countries including USA Japan Europe and China but until now designers have had no publication which provides practical guidance or accessible coverage of the fundamentals. This book fills this void. It deals with the fundamentals of composites and basic design principles and provides step-by-step guidelines for design. Its main theme is the repair and retrofit of un-reinforced reinforced and prestressed concrete structures using carbon glass and other high strength fibre composites. In the case of beams the focus is on their strengthening for flexure and shear or their stiffening. The main interest with columns is the improvement of their ductility; and both strengthening and ductility improvement of un-reinforced structures are covered. Methods for evaluating the strengthened structures are presented. Step by step procedures are set out including flow charts for the various structural components and design examples and practice problems are used to illustrate. As infrastructure ages worldwide and its demolition and replacement becomes less of an option the need for repair and retrofit of existing facilities will increase. Besides its audience of design professionals this book suits graduate and advanced undergraduate students. | FRP Composites for Reinforced and Prestressed Concrete Structures A Guide to Fundamentals and Design for Repair and Retrofit

GBP 56.99
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Indwelling Neural Implants Strategies for Contending with the In Vivo Environment

Indwelling Neural Implants Strategies for Contending with the In Vivo Environment

Despite enormous advances made in the development of external effector prosthetics over the last quarter century significant questions remain especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment examines many of these challenges paying particular attention to how the healing of tissues surrounding an implant can impact the intended use of a device. The contributions are divided into four sections · Part one examines wound healing from the initial insertion trauma through the inflammatory and repair process explaining how the action of healing varies throughout different areas of the body. · Part two considers various performance issues specific to particular implant components including those that arise from the chemical mechanical thermal and electrical impact on surrounding tissues. It discusses challenges that result from chronic tissue stimulation and heat effects that occur with on-chip and telemetric processing. · Part three presents both in vitro and in vivo approaches to assessing wound healing response to materials. It includes the contribution of the developer of a chronic hollow fiber membrane implant who explains how an in vivo model is used to assess molecular transport in brain tissue surrounding the implant. · The final section evaluates molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between the electrode surface and the surrounding tissue. It also presents novel approaches to nerve regeneration and repair. | Indwelling Neural Implants Strategies for Contending with the In Vivo Environment

GBP 59.99
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Biomaterials and Stem Cells in Regenerative Medicine

Biomaterials and Stem Cells in Regenerative Medicine

Work in the area of biomaterials and stem cell therapy has revealed great potential for many applications from the treatment of localized defects and diseases to the repair and replacement of whole organs. Researchers have also begun to develop a better understanding of the cellular environment needed for optimal tissue repair and regeneration. Biomaterials and Stem Cells in Regenerative Medicine explores a range of applications for biomaterials and stem cell therapy and describes recent research on suitable cell scaffolds and substrates for tissue repair and reconstruction. Featuring contributions by experts in the field the book explores important scientific and clinical aspects. It covers the basic science involved in structure and properties techniques and technological innovations in processing and characterization and applications of biomaterials and stem cells. Topics include: Polymeric systems for stem cell delivery The potential of membranes and porous scaffolds in tissue repair including myocardial periodontal ophthalmic and bone tissues The optimization of the interaction between stem cells and biomaterial substrates The source and nature of stem cells for tissue engineering applications The clinical translation of stem cell–based tissue engineering for regenerative medicine From fundamental principles to recent advances at the macro micro nano and molecular scales the book brings together current knowledge on biomaterials and stem cells in the context of regenerative medicine. It also stimulates discussion about future research directions. This unique book offers a valuable benchmark for the current status of clinically relevant research and development in stem cells and regenerative medicine. It bridges the gaps in experimental approaches and understanding among the materials science and engineering biological sciences and biomedical science and engineering communities making it a valuable reference for graduate students researchers and practitioners working in the multidisciplinary field of biomedical research.

GBP 69.99
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Mechanisms of Chemical Degradation of Cement-based Systems

Mechanisms of Chemical Degradation of Cement-based Systems

Deterioration of cement-based materials is a continuing problem as it results in the substantial shortening of the lives of conventional concrete structures. The main costs result from poor performance and the need for early repair. With more advanced applications where very long service lives are essential such as the storage of nuclear waste an understanding of the degradation processes in order to predict long term performance is very important. this book forms the proceedings of the latest Symposia at the Materials Research Society Autumn meeting in Boston. | Mechanisms of Chemical Degradation of Cement-based Systems

GBP 59.99
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Monitoring and Assessment of Structures

Monitoring and Assessment of Structures

This book details the latest methods available for the in-service assessment of buildings and other structures. Written by a team of international experts it provides detailed information and practical advice on key issues such as safety assessment and performance monitoring and evaluation. All the leading methodologies are covered including photogrammetry laser-based survey methods and dynamic monitoring. Visual inspection the most common assessment technique is also covered. New techniques and methodologies to minimise repair and maintenance costs and extend a structure's service life are described in detail. With numerous case studies practical examples and reference to the key international standards Monitoring and Assessment of Structures is a vital handbook for surveyors civil and structural engineers and all those involved in property management.

GBP 52.99
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Beyond Doer and Done to Recognition Theory Intersubjectivity and the Third

Beyond Doer and Done to Recognition Theory Intersubjectivity and the Third

In Beyond Doer and Done To Jessica Benjamin author of the path-breaking Bonds of Love expands her theory of mutual recognition and its breakdown into the complementarity of doer and done to. Her innovative theory charts the growth of the Third in early development through the movement between recognition and breakdown and shows how it parallels the enactments in the psychoanalytic relationship. Benjamin’s recognition theory illuminates the radical potential of acknowledgment in healing both individual and social trauma in creating relational repair in the transformational space of thirdness. Benjamin’s unique formulations of intersubjectivity make essential reading for both psychoanalytic therapists and theorists in the humanities and social sciences. | Beyond Doer and Done to Recognition Theory Intersubjectivity and the Third

GBP 46.99
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Character Costume Figure Drawing Step-by-Step Drawing Methods for Theatre Costume Designers

Character Costume Figure Drawing Step-by-Step Drawing Methods for Theatre Costume Designers

Character Costume Figure Drawing is an essential guide that will improve your drawing skills and costume renderings. Step-by-step visuals illustrate the how-tos of drawing body parts costumes accessories faces children and different character archetypes such as maternal elderly sassy sexy and evil. By focusing on the foundations of drawing bodies including body proportion bone structure body masses facial expressions and appendages this guide shows you how to develop sketches from stick figures to full-blown characters. The third edition features a new chapter Digital Mixed Media Costume Rendering. This chapter introduces the basic usages of Photoshop tools to enhance and improve costume designs in order to provide easy delivery design ideas to the director and design team provide easy changes and alterations during the design process virtually apply actual fabric swatches over costume sketches and help visualize lighting effects. | Character Costume Figure Drawing Step-by-Step Drawing Methods for Theatre Costume Designers

GBP 44.99
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The Physiology of Bioelectricity in Development Tissue Regeneration and Cancer

The Physiology of Bioelectricity in Development Tissue Regeneration and Cancer

Recent advances in technology have led to the unprecedented accuracy in measurements of endogenous electric fields around sites of tissue disruption. State-of-the-art molecular approaches demonstrate the role of bioelectricity in the directionality and speed of cell migration proliferation apoptosis differentiation and orientation. New information indicates that electric fields play a role in initiating and coordinating complex regenerative responses in development and wound repair and that they may also have a part in cancer progression and metastasis. Compiling current research in this rapidly expanding field Physiology of Bioelectricity in Development Tissue Regeneration and Cancer highlights relevant cutting-edge topics poised to drive the next generation of medical breakthroughs. Chapters consider methods for detecting endogenous electric field gradients and studying applied electric fields in the lab. The book addresses bioelectricity’s roles in guiding cell behavior during morphogenesis and orchestrating higher order patterning. It also covers the response of stem cells to applied electric fields which reveals bioelectricity as an exciting new player in tissue engineering and regenerative medicine. This book provides an in-depth exploration of how electric signals control corneal wound repair and skin re-epithelialization angiogenesis and inflammation. It also delves into the bioelectric responses of cells derived from the musculoskeletal system bioelectrical guidance of neurons and the beneficial application of voltage gradients to promote regeneration in the spinal cord. It concludes with a discussion of bioelectricity and cancer progression and the potential for novel cancer biomarkers new methods for early detection and bioelectricity-based therapies to target both the tumor and metastatic cancer cells. This multidisciplinary compilation will benefit biologists biochemists biomedical scientists engineers dermatologists and clinicians or anyone else interested in development regeneration cancer and tissue engineering. It can also serve as an ideal textbook for students in biology medicine medical physiology biophysics and biomedical engineering. | The Physiology of Bioelectricity in Development Tissue Regeneration and Cancer

GBP 69.99
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Intelligent Systems and Robotics

Intelligent Systems and Robotics

Intelligent Systems and Robotics focuses on new developments in robotics and intelligent systems and provides insight guidance and specific techniques vital to those concerned with the design and implementation of robotics and intelligent system applications. Intelligent Systems and Robotics presents information on a 3-D vision for robots and intelligent control of a vision-based reasoning system with a robot manipulator. The reader will find authoritative presentations on autonomous land vehicle navigation manipulator reachable workspace problems and the formulation of algorithms for their solution. Covered are methods for medical applications utilizing expert adaptive control the integrated piezoelectric sensor/actuator design for distributed identification and control of smart machines including theory experiments finite element formulation and analysis. Automatic repair of aircraft transparencies and geometric modeling utilized in robot task planning as well as the evaluation of standard fieldbus networks utilized in the factory environment are presented.

GBP 59.99
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Earthquake Engineering for Structural Design

Earthquake Engineering for Structural Design

Developments in Earthquake Engineering have focussed on the capacity and response of structures. They often overlook the importance of seismological knowledge to earthquake-proofing of design. It is not enough only to understand the anatomy of the structure you must also appreciate the nature of the likely earthquake. Seismic design as detailed in this book is the bringing together of Earthquake Engineering and Engineering Seismology. It focuses on the seismological aspects of design – analyzing various types of earthquake and how they affect structures differently. Understanding the distinction between these earthquake types and their different impacts on buildings can make the difference between whether a building stands or falls or at least to how much it costs to repair. Covering the basis and basics of the major international codes this is the essential guide for professionals working on structures in earthquake zones around the world. | Earthquake Engineering for Structural Design

GBP 69.99
1

Concrete in the Marine Environment

Concrete in the Marine Environment

Concrete has clearly emerged as the most economical and durable material for the building of the vast majority of marine structures. Reinforced concrete too has overcome the technological problems making it a suitable material for the construction of advanced marine structures such as offshore drilling platforms superspan bridges and undersea tunnels. As the world becomes increasingly ocean-oriented for energy and other resources it is predicted that construction activities during the 21st century will be dominated by concrete sea structures. The performance of concrete in the marine environment is presented here in a logical manner giving state-of-the-art reviews of the nature of the marine environment the composition and properties of concrete history of concrete performance in seawater major causes of deterioration of concrete in the marine environment selection of materials and mix proportioning for durable concrete recommended concrete practice and repair of deteriorated marine structures. It is of value to any design or construction engineer responsible for marine structures.

GBP 59.99
1

Automobile Electrical and Electronic Systems

Automobile Electrical and Electronic Systems

This textbook will help you learn all the skills you need to pass all Vehicle Electrical and Electronic Systems courses and qualifications. As electrical and electronic systems become increasingly more complex and fundamental to the workings of modern vehicles understanding these systems is essential for automotive technicians. For students new to the subject this book will help to develop this knowledge but will also assist experienced technicians in keeping up with recent technological advances. This new edition includes information on developments in pass-through technology multiplexing and engine control systems. In full colour and covering the latest course specifications this is the guide that no student enrolled on an automotive maintenance and repair course should be without. Designed to make learning easier this book contains: Photographs flow charts quick reference tables overview descriptions and step-by-step instructions. Case studies to help you put the principles covered into a real-life context. Useful margin features throughout including definitions key facts and ‘safety first’ considerations. | Automobile Electrical and Electronic Systems

GBP 43.99
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Restoring Justice An Introduction to Restorative Justice

Restoring Justice An Introduction to Restorative Justice

Restoring Justice: An Introduction to Restorative Justice Sixth Edition offers a clear and convincing explanation of restorative justice a movement within criminal justice with ongoing worldwide influence. The book explores the broad appeal of this vision and offers a brief history of its roots and development as an alternative to an impersonal justice system focused narrowly on the conviction and punishment of those who break the law. Instead restorative justice emphasizes repairing the harm caused or revealed by criminal behavior using cooperative processes that include all the stakeholders. The book presents the theory and principles of restorative justice and discusses its four cornerpost ideas: Inclusion Encounter Repair and Cohesion. Multiple models for how restorative justice may be incorporated into criminal justice are explored and the book proposes an approach to assessing the extent to which programs or systems are actually restorative in practice. The authors also suggest six strategic objectives to significantly expand the use and reach of restorative justice and recommended tactics to make progress towards the acceptance and adoption of restorative programs and systems. | Restoring Justice An Introduction to Restorative Justice

GBP 51.99
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The Klein Tradition Lines of Development—-Evolution of Theory and Practice over the Decades

The Klein Tradition Lines of Development—-Evolution of Theory and Practice over the Decades

Melanie Klein's extension of Freud's ideas - in particular her explorations into the world of the infant and her emphasis on the complex interactions between the infant's internal world of powerful primitive emotions of love and hate and the mothering that the infant receives - were greeted with skepticism but are now widely accepted as providing an invaluable way of understanding human cognitive and emotional development. Klein's insights shed light on persecuted states guilt the drive to create and to repair; they also provide the clinician with a theory of technique. Klein's work has inspired the work of psychoanalysts around the world. Her concept of projective identification with its implications for the understanding of countertransference made a significant impact on her followers and on psychoanalysts in other countries and from other schools of thought. Further exploration of these ideas has led to greater understanding of how change occurs in psychoanalysis and has inspired a large literature with a particular focus on technique. | The Klein Tradition Lines of Development—-Evolution of Theory and Practice over the Decades

GBP 69.99
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Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging

Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging

Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging provides a comprehensive overview of cell therapy imaging ranging from the basic biology of cell therapeutic choices to the preclinical and clinical applications of cell therapy. It emphasizes the use of medical imaging for therapeutic delivery/targeting cell tracking and determining therapeutic efficacy. The book first presents background information and insight on the major classes of stem and progenitor cells. It then describes the main imaging modalities and state-of-the-art techniques that are currently employed for stem cell tracking. In the final chapters leading scholars offer clinical perspectives on existing and potential uses of stem cells as well as the impact of image-guided delivery and tracking in major organ systems. Through clear descriptions and color images this volume illustrates how noninvasive imaging is used to track stem cells as they repair damaged tissue in the body. With contributions from some of the most prominent preclinical and clinical researchers in the field the book helps readers to understand the evolving concepts of stem cell labeling and tracking as the field continues to move forward.

GBP 46.99
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Corrosion Protection for the Oil and Gas Industry Pipelines Subsea Equipment and Structures

Corrosion Protection for the Oil and Gas Industry Pipelines Subsea Equipment and Structures

Corrosion Protection for the Oil and Gas Industry: Pipelines Subsea Equipment and Structures summarizes the main causes of corrosion and requirements for materials protection selection of corrosion-resistant materials and coating materials commonly used for corrosion protection and the limitations to their use application and repair. This book focuses on the protection of steels against corrosion in an aqueous environment either immersed in seawater or buried. It also includes guidelines for the design of cathodic protection systems and reviews of cathodic protection methods materials installation and monitoring. It is concerned primarily with the external and internal corrosion protection of onshore pipelines and subsea pipelines but reference is also made to the protection of other equipment subsea structures risers and shore approaches. Two case studies design examples and the author’s own experiences as a pipeline integrity engineer are featured in this book. Readers will develop a high quality and in-depth understanding of the corrosion protection methods available and apply them to solve corrosion engineering problems. This book is aimed at students practicing engineers and scientists as an introduction to corrosion protection for the oil and gas industry as well as to overcoming corrosion issues. | Corrosion Protection for the Oil and Gas Industry Pipelines Subsea Equipment and Structures

GBP 46.99
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Historic Bridges Evaluation Preservation and Management

Historic Bridges Evaluation Preservation and Management

Explore Historic Bridge Design through the Perspective of Modern Engineering Historic Bridges:Evaluation Preservation and Management provides both an admiring and a technical account of bridge engineering through an exploration of several remarkable examples. From ancient China to modern-day Minnesota the book discusses the history and structural evaluation of bridges as well as their preservation and restoration. With chapters written by renowned engineers this unique resource — Compares the techniques and materials used in building three railroad bridges that traversed the Mississippi at the same site in 1865 1887 and 1910 Investigates a legendary stone-arch bridge constructed in Ancient China in 606 A. D. Demonstrates how historians and engineers in Milwaukee found an approach to new bridge design that balances modern design standards with aesthetic interpretation Details a collaborative team approach to historic bridge management in Minnesota Considers the design and repair process of rapidly disappearing wrought iron bridges Discusses preservation of stone masonry aqueducts on the Chesapeake and Ohio Canal An educational treatise for engineers and historical preservationists this work includes a wealth of illustrations and scientific tables. Demonstrating historic engineering significance beyond their utilitarian function the bridges encountered in these pages are true landmarks as worthy of emulation as they are preservation. | Historic Bridges Evaluation Preservation and Management

GBP 59.99
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