Pricemate

Cellular Analysis by Atomic Force Microscopy

Despite substantial evidence showing the feasibility of Atomic Force Microscopy (AFM) to identify cells with altered elastic and adhesive properties the use of this technique as a complementary diagnostic method remains controversial. This book is designed to be a practical textbook that teaches how to assess the mechanical characteristics of living individual cells by AFM. Following a step-by-step approach it introduces the methodology of measurements in the case of both determination of elastic properties and quantification of adhesive properties. | Cellular Analysis by Atomic Force Microscopy

GBP 95.00

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Microbial Infections and Cancer Therapy

This book deals with the emerging concept that certain pathogenic bacteria and viruses when infecting people with cancer actively fight tumors allowing their regression. Although such observations go back more than 100 years use of specific bacterial strains or viruses usually genetically modified with known anticancer drugs and their protein/peptide products has gained ground in recent years allowing significant cancer regression in clinical trials with stage III/IV cancer patients or even in pediatric brain tumor patients often without any demonstration of toxicity. It is composed of 12 chapters written by pioneers in microbial biotech and cancer research and covers the emerging roles of various microorganisms and their products in cancer therapy. The book highlights the benefits of using conventional cancer treatments (such as chemo- and radiotherapies) with microbial-based therapies. Such combinatorial therapies have gained particular attention as a strategy to overcome drug resistance and the readers of the book will discover their impact on fundamental research and promising results from clinical trials. | Microbial Infections and Cancer Therapy

GBP 139.00

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Applied Bohmian Mechanics From Nanoscale Systems to Cosmology

Most textbooks explain quantum mechanics as a story where each step follows naturally from the one preceding it. However the development of quantum mechanics was exactly the opposite. It was a zigzag route full of personal disputes where scientists were forced to abandon well-established classical concepts and to explore new and imaginative pathways. Some of the explored routes were successful in providing new mathematical formalisms capable of predicting experiments at the atomic scale. However even such successful routes were painful enough so that relevant scientists like Albert Einstein and Erwin Schrödinger decided not to support them. In this book the authors demonstrate the huge practical utility of another of these routes in explaining quantum phenomena in many different research fields. Bohmian mechanics the formulation of the quantum theory pioneered by Louis de Broglie and David Bohm offers an alternative mathematical formulation of quantum phenomena in terms of quantum trajectories. Novel computational tools to explore physical scenarios that are currently computationally inaccessible such as many-particle solutions of the Schrödinger equation can be developed from it. | Applied Bohmian Mechanics From Nanoscale Systems to Cosmology

GBP 116.00

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Environmental Ethical and Economical Issues of Nanotechnology

Nanotechnology is moving out of its comfort zone of scientific discourse. As new products go to market and national and international organizations roll out public-engagement programs on nanotechnology to discuss environmental and health issues various sectors of the public are beginning to discuss what the controversy is all about. Nongovernmental organizations have long since reacted; however now the social sciences have begun to study the cultural phenomenon of nanotechnology thus extending discourses and opening out nanotechnology to whole new social dimensions. These dimensions and their newly constructed imaginings around nanotechnology intersect with the ecology health governance economy and illusory futures. There is always a need for more than just an ELSI (ethical legal and social implications) sideshow within nanotechnology. The collective public imaginings of nanotechnology include tangles of science and science fiction local enterprises and global transformation all looking forward toward a sustainable future while looking back on the past debates on science and nature. This book highlights the environmental health and economical concerns of nanotechnology and discusses its future research directions. It provides academia and industry a high-tech start-up that will revolutionize modern practices. With little and outdated literature available on the topic this timely book will be helpful for the readers as it thoroughly covers the environmental ethical and economical issues of nanotechnology.

GBP 76.99

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Plasma Applications for Material Modification From Microelectronics to Biological Materials

This book is an up-to-date review of the most important plasma-based techniques for material modification from microelectronics to biological materials and from fusion plasmas to atmospheric ones. Each its technical chapters is written by long-experienced internationally recognised researchers. The book provides a deep and comprehensive insight into plasma technology and its associated elemental processes and is illustrated throughout with excellent figures and references to complement each section. Although some of the topics covered can be traced back several decades care has been taken to emphasize the most recent findings and expected evolution. The first time the word ‘plasma’ appeared in print in a scientific text related to the study of electrical discharges in gases was 1928 when Irving Langmuir published his article ‘Oscillations in Ionized Gases’. It was the baptism of the predominant state of matter in the known universe (it is estimated that up to 99% of matter is plasma) although not on earth where the conditions of pressure and temperature make normal the states of matter (solid liquid gas) which in global terms are exotic. It is enough to add energy to a solid (in the form of heat or electromagnetic radiation) to go into the liquid state from which gas is obtained through an additional supply of energy. If we continue adding energy to the gas we will partially or totally ionise it and reach a new state of matter plasma made up of free electrons atoms and molecules (electrically neutral particles) and ions (endowed with a positive or a negative electric charge). | Plasma Applications for Material Modification From Microelectronics to Biological Materials

GBP 116.00

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Analysis of Structures by Matrix Methods

The analysis of engineering structures has always been a challenge to engineers and in the past classical methods were used to quantify the response of a structure to the applied forces. These methods were suitable for the analysis of relatively simple structures that could be solved by hand calculations but complicated structures had to be simplified to a model that could be solved by classical methods. The results however were approximations depending on the modifications made to the structure as well as on the experience and judgement of the analyst. These limitations led to the derivation of the slope-deflection equations for continuous beams and later formulation of the moment distribution method. With the advent of electronic computers systematic procedures for the analysis of structures have been developed. Computer programs help in obtaining required solutions to the simultaneous equations in the case of structures where the number of equations is large and hand calculations are not suitable. The detailed work with simultaneous equations can be made in a general and compact form by using matrix notation leading to the development of the matrix methods of structural analysis. This book deals with the analysis of engineering structures made of skeletal members and covers the type of structures that are commonly used in practice. It builds up on the subject matter dealing with matrix algebra analysis of bar elements special forms of members stability and vibration of structures and pin-connected rigid-plane and 3D frames. It treats the important step of formulating the overall stiffness matrix of a structure in a systematic and straightforward manner and uses simple mathematical approaches wherever possible. The book is reader friendly particularly for beginners who have no prior knowledge in this subject and can also be used as a textbook by undergraduate and postgraduate students studying for a degree in civil structural or mechanical engineering as well as by practicing engineers who have not studied this subject but are using software packages that deal with the analysis of engineering structures. | Analysis of Structures by Matrix Methods

GBP 139.00

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Three Daughters Three Journeys Quest for Cancer Cure

Cancer threatens the lives of people around the world. Women in particular are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60 these inheritable cancers threaten women’s lives health and fertility even when they are young before most would even begin to go for annual mammogram screenings to check for breast cancer. Three Daughters Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena a Polish oncology nurse has spent her life treating child patients with cancer. Then she confronts it in her own family and her own body. Kamola a rural Indian girl knows she has symptoms of the same disease that took her mother but feels afraid to discuss it with her father and brothers knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra a doctor testing a new treatment called Neelazin using a bacterial anticancer protein in food to destroy cancer cells. Selena a wealthy woman of color in Chicago finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment Selena dedicates her life to providing affordable homes and counseling to families affected by the disease. Although the drug Neelazin is fictional the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs as these drugs can enter both normal and cancer cells though preferably cancer cells causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets thereby becoming resistant to the drugs as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein–protein complex formation thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer rather than removing the healthy tissue of the breasts and ovaries. Hopefully they would not have to choose between fertility and survival as is the implied message in this book fictional as it is at this time. | Three Daughters Three Journeys Quest for Cancer Cure

GBP 31.99

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