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Internet of Things (IoT) Systems and Applications

The Newman Lectures on Thermodynamics

Pharmaceutical Biocatalysis Fundamentals Enzyme Inhibitors and Enzymes in Health and Diseases

Pharmaceutical Biocatalysis Fundamentals Enzyme Inhibitors and Enzymes in Health and Diseases

This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors rare diseases orphan drugs the costs of drug development and therapies and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions carboxylesterase inhibitors for pharmaceutical applications employment of inhibitors for the treatment of neurodegenerative diseases use of engineered proteins bioactive peptides and fibrinolytic enzymes for thrombolytic therapy and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance computer-aided drug design for the identification of multi-target directed ligands and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs. | Pharmaceutical Biocatalysis Fundamentals Enzyme Inhibitors and Enzymes in Health and Diseases

GBP 193.00
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Nanomaterials in Architecture and Art Conservation

Nanomaterials in Architecture and Art Conservation

The conservation and protection of buildings that constitute our cultural heritage are complex tasks calling for a comprehensive knowledge of the historical background of the buildings as well as the construction technologies and materials used. Nanomaterials in Architecture and Art Conservation gives a comprehensive overview of the state of the art of using nanomaterials in conservation sciences mainly for stone mortar and plaster strengthening but also for the consolidation of wall paintings. The book compiles and details deterioration mechanisms of stone and historical mortars as well as methods of characterising and testing consolidation effects. The non- or semi-destructive characterisation methods that will be presented allow additional measurements to characterise objects before and after any interventions. Besides general aspects of inorganic consolidants are targeted. The focus in particular is the application of nanolime as a new consolidation agent. Basic characteristics and application advices as well as beneficial combinations with other consolidation agents such as silicic acid esters are emphasised. What makes this book so special is the large number of practical applications described from the viewpoint of different restorers offering a direct inside view of the procedure for the conservation of historical monuments. Restorers dealing with stone mortar and plaster conservation; artists; advanced undergraduate- and graduate-level students of conservation science art and nanotechnology; offices for the protection of monuments and heritage agencies; and researchers in materials science conservation nanotechnology and chemistry especially those with an interest in applied sciences will find this book a great reference.

GBP 139.00
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