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Human Molecular Genetics

Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics genomics and cell biology. Maintaining the features that have made previous editions so popular this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized coverage of newer DNA sequencing technologies has been expanded and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS functional genomics stem cells and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation. Key features: Fully integrated approach to the molecular aspects of human genetics genomics and cell biology Accessible text is supported and enhanced throughout by superb artwork illustrating the key concepts and mechanisms Summary boxes at the end of each chapter provide clear learning points Annotated further reading helps readers navigate the wealth of additional information in this complex subject and provides direction for further study Reorganized into five sections for improved access to related topics Also new to this edition – brand new chapter on evolution and anthropology from the authors of the highly acclaimed Human Evolutionary Genetics A proven and popular textbook for upper-level undergraduates and graduate students the new edition of Human Molecular Genetics remains the ‘go-to’ book for those studying human molecular genetics or genomics courses around the world.

GBP 74.99

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Cellular Signal Processing An Introduction to the Molecular Mechanisms of Signal Transduction

Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology biochemistry bioinformatics and pharmacology as well as medical students. The text is organized by three key topics central to signal transduction: the protein network its energy supply and its evolution. It covers all important aspects of cell signaling ranging from prokaryotic signal transduction to neuronal signaling and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes as well as content on new developments in systems biology epigenetics redox signaling and small non-coding RNA signaling. | Cellular Signal Processing An Introduction to the Molecular Mechanisms of Signal Transduction

GBP 66.99

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Molecular Biology Structure and Dynamics of Genomes and Proteomes

Molecular Biology: Structure and Dynamics of Genomes and Proteomes second edition illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA RNA and proteins. Emphasis is on the experimental basis of discovery and the most recent advances in the field while presenting a rigorous yet still concise summary of the structural mechanisms of molecular biology. Topics new to this edition include the CRISPR-Cas gene editing system Coronaviruses – structure genome vaccine and drug development and newly recognized mechanisms for transcription termination. The text is written for advanced undergraduate or graduate-level courses in molecular biology. Key Features Highlights the experimental basis of important discoveries in molecular biology Thoroughly updated with new information on gene editing tools viruses and transcription mechanisms termination and antisense Provides learning objectives for each chapter Includes a list of relevant videos from the Internet about the topics covered in the chapter | Molecular Biology Structure and Dynamics of Genomes and Proteomes

GBP 64.99

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Understanding Cancer An Introduction to the Biology Medicine and Societal Implications of this Disease

Understanding Cancer is a brand new undergraduate textbook for students without prior training in biology that integrates an introduction to cancer medicine with descriptions of the biological processes that go wrong to cause cancer’s onset and progression. It also highlights the human side of cancer with stories of patients and loved ones touched by the disease dealing with diagnosis treatment and the prospect of death as well as the broader societal aspects of cancer and its prevention. Key discoveries that have improved our understanding of cancer are presented in sidebars. In spite of this diversity the book maintains precision and simplicity in describing what is and is not known about cancer describing the strengths and limitations of current treatments | Understanding Cancer An Introduction to the Biology Medicine and Societal Implications of this Disease

GBP 48.99

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Bacterial Genetics and Genomics

Our understanding of bacterial genetics has progressed as the genomics field has advanced. Genetics and genomics complement and influence each other; they are inseparable. Under the novel insights from genetics and genomics once-believed borders in biology start to fade: biological knowledge of the bacterial world is being viewed under a new light and concepts are being redefined. Species are difficult to delimit and relationships within and between groups of bacteria – the whole concept of a tree of life – is hotly debated when dealing with bacteria. The DNA within bacterial cells contains a variety of features and signals that influence the diversity of the microbial world. This text assumes readers have some knowledge of genetics and microbiology but acknowledges that it can be varied. Therefore the book includes all of the information that readers need to know in order to understand the more advanced material in the book. | Bacterial Genetics and Genomics

GBP 66.99

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A First Course in Systems Biology

A First Course in Systems Biology is an introduction for advanced undergraduate and graduate students to the growing field of systems biology. Its main focus is the development of computational models and their applications to diverse biological systems. The book begins with the fundamentals of modeling then reviews features of the molecular inventories that bring biological systems to life and discusses case studies that represent some of the frontiers in systems biology and synthetic biology. In this way it provides the reader with a comprehensive background and access to methods for executing standard systems biology tasks understanding the modern literature and launching into specialized courses or projects that address biological questions using theoretical and computational means. New topics in this edition include: default modules for model design limit cycles and chaos parameter estimation in Excel model representations of gene regulation through transcription factors derivation of the Michaelis-Menten rate law from the original conceptual model different types of inhibition hysteresis a model of differentiation system adaptation to persistent signals nonlinear nullclines PBPK models and elementary modes. The format is a combination of instructional text and references to primary literature complemented by sets of small-scale exercises that enable hands-on experience and large-scale often open-ended questions for further reflection.

GBP 82.99

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Biology of Aging

Biology of Aging Second Edition presents the biological principles that have led to a new understanding of the causes of aging and describes how these basic principles help one to understand the human experience of biological aging longevity and age-related disease. Intended for undergraduate biology students it describes how the rate of biological aging is measured; explores the mechanisms underlying cellular aging; discusses the genetic pathways that affect longevity in various organisms; outlines the normal age-related changes and the functional decline that occurs in physiological systems over the lifespan; and considers the implications of modulating the rate of aging and longevity. The book also includes end-of-chapter discussion questions to help students assess their knowledge of the material. Roger McDonald received his Ph. D. from the University of Southern California and is Professor Emeritus in the Department of Nutrition at the University of California Davis. Dr. McDonald’s research focused on mechanisms of cellular aging and the interaction between nutrition and aging. His research addressed two key topics in the field: the relationship between dietary restriction and lifespan and the effect of aging on circadian rhythms and hypothalamic regulation. You can contact Dr. McDonald at rbmcdonald@ucdavis. edu. Related Titles Ahmad S. I. ed. Aging: Exploring a Complex Phenomenon (ISBN 978-1-1381-9697-1) Moody H. R. & J. Sasser. Gerontology: The Basics (ISBN 978-1-1387-7582-4) Timiras P. S. Physiological Basis of Aging and Geriatrics (ISBN 978-0-8493-7305-3)

GBP 56.99

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Biology for the Health Sciences Mechanisms of Disease

Biology is central to our understanding of health and disease and to the development of effective treatments and thus it is critical that health professionals have a solid grounding and knowledge comfort in the pathogenesis and mechanisms of disease processes. This innovative new textbook draws these topics together providing an accessible introduction across four central disciplines - basic biology biotechnology non-infectious disease and infectious disease. Key Features: Provides students of biology and those going into health care professions with a strong foundation to understand the pathogenesis of disease at the molecular and cellular level Focuses on the etiology and pathophysiology of the major human diseases by body system including diabetes and nutritional disorders cardiovascular disease neurodegenerative diseases and cancer aligned to medicine and health science course structure Covers mechanisms of infectious disease transmission as well as disease pathophysiology and considers the impact of antibiotic resistance Reviews the applications of biotechnology and genomics to human health in diagnosis and treatment as well as to our understanding of disease and disease surveillance Each chapter contains a mini glossary of key terms and associated definitions and review questions allow students to assess how much of the chapter they have understood Digital resources accompany the textbook such as interactive quizzes for students to engage with and figure slides of the book's illustrations that instructors can use in lectures Enhanced throughout with plentiful illustrations Biology for the Health Sciences is an essential companion for any student of the health sciences and for biological science students studying the causes of disease as part of a wider course. | Biology for the Health Sciences Mechanisms of Disease

GBP 49.99

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Cell Boundaries How Membranes and Their Proteins Work

The central themes of Cell Boundaries concern the structural and organizational principles underlying cell membranes and how these principles enable function. By building a biological and biophysical foundation for understanding the organization of lipids in bilayers and the folding assembly stability and function of membrane proteins the book aims to broaden the knowledge of bioscience students to include the basic physics and physical chemistry that inform us about membranes. In doing so it is hoped that physics students will find familiar territory that will lead them to an interest in biology. Our progress toward understanding membranes and membrane proteins depends strongly upon the concerted use of both biology and physics. It is important for students to know not only what we know but how we have come to know it so Cell Boundaries endeavours to bring out the history behind the central discoveries especially in the early chapters where the foundation is laid for later chapters. Science is far more interesting if as students we can appreciate and share in the adventures—and misadventures—of discovering new scientific knowledge. Cell Boundaries was written with advanced undergraduates and beginning graduate students in the biological and physical sciences in mind though this textbook will likely have appeal to researchers and other academics as well. Highlights the history of important central discoveries Early chapters lay the foundation for later chapters to build on so knowledge is amassed High-quality line diagrams illustrate key concepts and illuminate molecular mechanisms Box features and spreads expand on topics in main text including histories of discoveries special techniques and applications | Cell Boundaries How Membranes and Their Proteins Work

GBP 82.99

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Plants People and Culture The Science of Ethnobotany

Is it possible that plants have shaped the very trajectory of human cultures? Using riveting stories of fieldwork in remote villages two of the world’s leading ethnobotanists argue that our past and our future are deeply intertwined with plants. Creating massive sea craft from plants indigenous shipwrights spurred the navigation of the world’s oceans. Today indigenous agricultural innovations continue to feed clothe and heal the world’s population. One out of four prescription drugs for example were discovered from plants used by traditional healers. Objects as common as baskets for winnowing or wooden boxes to store feathers were ornamented with traditional designs demonstrating the human ability to understand our environment and to perceive the cosmos. Throughout the world the human body has been used as the ultimate canvas for plant-based adornment as well as indelible design using tattoo inks. Plants also garnered religious significance both as offerings to the gods and as a doorway into the other world. Indigenous claims that plants themselves are sacred is leading to a startling reformulation of conservation. The authors argue that conservation goals can best be achieved by learning from rather than opposing indigenous peoples and their beliefs. KEY FEATURES • An engrossing narrative that invites the reader to personally engage with the relationship between plants people and culture • Full-color illustrations throughout—including many original photographs captured by the authors during fieldwork • New to this edition—Plants That Harm a chapter that examines the dangers of poisonous plants and the promise that their study holds for novel treatments for some of our most serious diseases including Alzheimer’s and substance addiction • Additional readings at the end of each chapter to encourage further exploration • Boxed features on selected topics that offer further insight • Provocative questions to facilitate group discussion Designed for the college classroom as well as for lay readers this update of Plants People and Culture entices the reader with firsthand stories of fieldwork spectacular illustrations and a deep respect for both indigenous peoples and the earth’s natural heritage. | Plants People and Culture The Science of Ethnobotany

GBP 42.99

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