9 results (0,13209 seconds)

Brand

Merchant

Price (EUR)

Reset filter

Products
From
Shops

Natural Language Processing in the Real World Text Processing Analytics and Classification

Bayesian Analysis with R for Drug Development Concepts Algorithms and Case Studies

Bayesian Analysis with R for Drug Development Concepts Algorithms and Case Studies

Drug development is an iterative process. The recent publications of regulatory guidelines further entail a lifecycle approach. Blending data from disparate sources the Bayesian approach provides a flexible framework for drug development. Despite its advantages the uptake of Bayesian methodologies is lagging behind in the field of pharmaceutical development. Written specifically for pharmaceutical practitioners Bayesian Analysis with R for Drug Development: Concepts Algorithms and Case Studies describes a wide range of Bayesian applications to problems throughout pre-clinical clinical and Chemistry Manufacturing and Control (CMC) development. Authored by two seasoned statisticians in the pharmaceutical industry the book provides detailed Bayesian solutions to a broad array of pharmaceutical problems. Features Provides a single source of information on Bayesian statistics for drug development Covers a wide spectrum of pre-clinical clinical and CMC topics Demonstrates proper Bayesian applications using real-life examples Includes easy-to-follow R code with Bayesian Markov Chain Monte Carlo performed in both JAGS and Stan Bayesian software platforms Offers sufficient background for each problem and detailed description of solutions suitable for practitioners with limited Bayesian knowledge Harry Yang Ph. D. is Senior Director and Head of Statistical Sciences at AstraZeneca. He has 24 years of experience across all aspects of drug research and development and extensive global regulatory experiences. He has published 6 statistical books 15 book chapters and over 90 peer-reviewed papers on diverse scientific and statistical subjects including 15 joint statistical works with Dr. Novick. He is a frequent invited speaker at national and international conferences. He also developed statistical courses and conducted training at the FDA and USP as well as Peking University. Steven Novick Ph. D. is Director of Statistical Sciences at AstraZeneca. He has extensively contributed statistical methods to the biopharmaceutical literature. Novick is a skilled Bayesian computer programmer and is frequently invited to speak at conferences having developed and taught courses in several areas including drug-combination analysis and Bayesian methods in clinical areas. Novick served on IPAC-RS and has chaired several national statistical conferences. | Bayesian Analysis with R for Drug Development Concepts Algorithms and Case Studies

GBP 38.99
1

Meaningful Futures with Robots Designing a New Coexistence

Meaningful Futures with Robots Designing a New Coexistence

Soon robots will leave the factories and make their way into living rooms supermarkets and care facilities. They will cooperate with humans in everyday life taking on more than just practical tasks. How should they communicate with us? Do they need eyes a screen or arms? Should they resemble humans? Or may they enrich social situations precisely because they act so differently from humans? Meaningful Futures with Robots: Designing a New Coexistence provides insight into the opportunities and risks that arise from living with robots in the future anchored in current research projects on everyday robotics. As well as generating ideas for robot developers and designers it also critically discusses existing theories and methods for social robotics from different perspectives - ethical design artistical and technological – and presents new approaches to meaningful human-robot interaction design. Key Features: Provides insights into current research on robots from different disciplinary angles with a particular focus on a value-driven design. Includes contributions from designers psychologists engineers philosophers artists and legal scholars among others. Licence line: Chapters 1 3 12 and 15 of this book are available for free in PDF format as Open Access from the individual product page at www. crcpress. com. They have been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4. 0 license. | Meaningful Futures with Robots Designing a New Coexistence

GBP 44.99
1

Benefit-Risk Assessment in Pharmaceutical Research and Development

Benefit-Risk Assessment in Pharmaceutical Research and Development

Many practitioners in the pharmaceutical industry are still largely unfamiliar with benefit-risk assessment despite its growing prominence in drug development and commercialization. Helping to alleviate this knowledge gap Benefit-Risk Assessment in Pharmaceutical Research and Development provides a succinct overview of the key considerations relevant to benefit-risk assessment across the pharmaceutical R&D spectrum from early clinical development to late-stage development to regulatory review to post-launch assessment. The book first presents interpretations of benefit and risk in the context of a molecule moving from preclinical evaluation into its early testing in humans. It next considers benefit and risk characterization and assessment during a molecule’s journey from its clinical evaluation in humans through its submission to regulators for marketing approval. Throughout these sections the book offers insight into the role of benefit-risk assessment in heightening understanding among key stakeholders by shaping questions and guiding discussions among scientists physicians developers and regulatory agencies. The book also focuses on a molecule’s entry into the marketplace as a drug available for consumption by people. It explores the role of benefit-risk assessment as the relevance of carefully collected clinical efficacy and safety metrics fades in the wake of real-world use and evidence of effectiveness and safety. Bringing together the expertise of 15 contributors from academia and the industry this book offers an easy-to-read guide to the various facets of benefit-risk assessment in the major stages of pharmaceutical R&D. Suitable for those in both technical and managerial roles it enables readers to communicate more effectively across their development chain as well as rationally and thoughtfully embed benefit-risk assessment into their R&D processes.

GBP 44.99
1

Performance Reliability and Availability Evaluation of Computational Systems Volume I Performance and Background

Performance Reliability and Availability Evaluation of Computational Systems Volume I Performance and Background

This textbook intends to be a comprehensive and substantially self-contained two-volume book covering performance reliability and availability evaluation subjects. The volumes focus on computing systems although the methods may also be applied to other systems. The first volume covers Chapter 1 to Chapter 14 whose subtitle is ``Performance Modeling and Background. The second volume encompasses Chapter 15 to Chapter 25 and has the subtitle ``Reliability and Availability Modeling Measuring and Workload and Lifetime Data Analysis. This text is helpful for computer performance professionals for supporting planning design configuring and tuning the performance reliability and availability of computing systems. Such professionals may use these volumes to get acquainted with specific subjects by looking at the particular chapters. Many examples in the textbook on computing systems will help them understand the concepts covered in each chapter. The text may also be helpful for the instructor who teaches performance reliability and availability evaluation subjects. Many possible threads could be configured according to the interest of the audience and the duration of the course. Chapter 1 presents a good number of possible courses programs that could be organized using this text. Volume I is composed of the first two parts besides Chapter 1. Part I gives the knowledge required for the subsequent parts of the text. This part includes six chapters. It covers an introduction to probability descriptive statistics and exploratory data analysis random variables moments covariance some helpful discrete and continuous random variables Taylor series inference methods distribution fitting regression interpolation data scaling distance measures and some clustering methods. Part II presents methods for performance evaluation modeling such as operational analysis Discrete-Time Markov Chains (DTMC) and Continuous Time Markov Chains (CTMC) Markovian queues Stochastic Petri nets (SPN) and discrete event simulation. | Performance Reliability and Availability Evaluation of Computational Systems Volume I Performance and Background

GBP 120.00
1

Digital Afterlife Death Matters in a Digital Age

Digital Afterlife Death Matters in a Digital Age

Despite the range of studies into grief and mourning in relation to the digital research to date largely focuses on the cultural practices and meanings that are played out in and through digital environments. Digital Afterlife brings together experts from diverse fields who share an interest in Digital Afterlife and the wide-ranging issues that relate to this. The book covers a variety of matters that have been neglected in other research texts for example: The legal ethical and philosophical conundrums of Digital Afterlife The ways digital media are currently being used to expand the possibilities of commemorating the dead and managing the grief of those left behind Our lives are shaped by and shape the creation of our Digital Afterlife as the digital has become a taken for granted aspect of human experience. This book will be of interest to undergraduates from computing theology business studies philosophy psychology sociology and education from all types of institutions. Secondary audiences include researchers and postgraduate researchers with an interest in the digital. At a practical level the cost of data storage and changing data storage systems mitigate the likelihood of our digital presence existing in perpetuity. Whether we create accidental or intentional digital memories this has psychological consequences for ourselves and for society. Essentially the foreverness of forever is in question. Maggi Savin-Baden is Professor of Higher Education Research at the University of Worcester. She has a strong publication record of over 50 research publications and 17 books. Victoria Mason-Robbie is a Chartered Psychologist and an experienced lecturer having worked in the Higher Education sector for over 15 years. Her current research focuses on evaluating web-based avatars pedagogical agents and virtual humans. | Digital Afterlife Death Matters in a Digital Age

GBP 44.99
1

Student Solutions Manual for Gallian's Contemporary Abstract Algebra

Student Solutions Manual for Gallian's Contemporary Abstract Algebra

Whereas many partial solutions and sketches for the odd-numbered exercises appear in the book the Student Solutions Manual written by the author has comprehensive solutions for all odd-numbered exercises and large number of even-numbered exercises. This Manual also offers many alternative solutions to those appearing in the text. These will provide the student with a better understanding of the material. This is the only available student solutions manual prepared by the author of Contemporary Abstract Algebra Tenth Edition and is designed to supplement that text. Table of Contents Integers and Equivalence Relations0. Preliminaries Groups1. Introduction to Groups 2. Groups 3. Finite Groups; Subgroups 4. Cyclic Groups 5. Permutation Groups 6. Isomorphisms 7. Cosets and Lagrange's Theorem 8. External Direct Products 9. Normal Subgroups and Factor Groups 10. Group Homomorphisms 11. Fundamental Theorem of Finite Abelian Groups Rings12. Introduction to Rings 13. Integral Domains14. Ideals and Factor Rings 15. Ring Homomorphisms 16. Polynomial Rings 17. Factorization of Polynomials 18. Divisibility in Integral Domains FieldsFields19. Extension Fields 20. Algebraic Extensions21. Finite Fields 22. Geometric Constructions Special Topics23. Sylow Theorems 24. Finite Simple Groups 25. Generators and Relations 26. Symmetry Groups 27. Symmetry and Counting 28. Cayley Digraphs of Groups 29. Introduction to Algebraic Coding Theory 30. An Introduction to Galois Theory 31. Cyclotomic Extensions Biography Joseph A. Gallian earned his PhD from Notre Dame. In addition to receiving numerous national awards for his teaching and exposition he has served terms as the Second Vice President and the President of the MAA. He has served on 40 national committees chairing ten of them. He has published over 100 articles and authored six books. Numerous articles about his work have appeared in the national news outlets including the New York Times the Washington Post the Boston Globe and Newsweek among many others. | Student Solutions Manual for Gallian's Contemporary Abstract Algebra

GBP 44.99
1

A Beginners Guide to Amazon Web Services

A Beginners Guide to Amazon Web Services

Amazon Web Services (AWS) provides on-demand cloud computing platforms and application programming interfaces (APIs) to individuals companies and govern- ments along with distributed computing processing capacity and software tools via AWS server farms. This text presents a hands-on approach for beginners to get started with Amazon Web Services (AWS) in a simple way. Key Features It discusses topics such as Amazon Elastic Compute Cloud Elastic Load Balancing Auto Scaling Groups and Amazon Simple Storage Service. It showcases Amazon Web Services’ identity access management resources and attribute-based access control. It covers serverless computing services Virtual Private Cloud Amazon Aurora and Amazon Comprehend. It explains Amazon Web Services Free Tier Amazon Web Services Marketplace and Amazon Elastic Container Service. It includes security in Amazon Web Services the shared responsibilitymodel and high-performance computing on Amazon Web Services. The text is primarily written for graduate students professionals and academic researchers working in the fields of computer science engineering and information technology. Parul Dubey is currently working as an Assistant professor in the Department of Artificial Intelligence at G H Raisoni College of Engineering Nagpur India. She has filed for 15 Indian patents. She is responsible for about 10 publications in conference proceedings Scopus and journals. She has contributed book chapters in an edited book published by CRC Press and other reputed publishers. She is also an AWS Certified Cloud Practitioner. Rohit Raja is working as an associate professor and head in the Department of Information Technology at Guru Ghasidas Vishwavidyalaya Bilaspur India. His research interests include facial recognition signal processing networking and data mining. He has pub- lished 100 research papers in various international and national journals (including publications by the IEEE Springer etc. ) and proceedings of reputed international and national conferences (again including publications by Springer and the IEEE). | A Beginners Guide to Amazon Web Services

GBP 89.99
1

Bayesian Applications in Pharmaceutical Development

Bayesian Applications in Pharmaceutical Development

The cost for bringing new medicine from discovery to market has nearly doubled in the last decade and has now reached $2. 6 billion. There is an urgent need to make drug development less time-consuming and less costly. Innovative trial designs/ analyses such as the Bayesian approach are essential to meet this need. This book will be the first to provide comprehensive coverage of Bayesian applications across the span of drug development from discovery to clinical trial to manufacturing with practical examples. This book will have a wide appeal to statisticians scientists and physicians working in drug development who are motivated to accelerate and streamline the drug development process as well as students who aspire to work in this field. The advantages of this book are: Provides motivating worked practical case examples with easy to grasp models technical details and computational codes to run the analyses Balances practical examples with best practices on trial simulation and reporting as well as regulatory perspectives Chapters written by authors who are individual contributors in their respective topics Dr. Mani Lakshminarayanan is a researcher and statistical consultant with more than 30 years of experience in the pharmaceutical industry. He has published over 50 articles technical reports and book chapters besides serving as a referee for several journals. He has a PhD in Statistics from Southern Methodist University Dallas Texas and is a Fellow of the American Statistical Association. Dr. Fanni Natanegara has over 15 years of pharmaceutical experience and is currently Principal Research Scientist and Group Leader for the Early Phase Neuroscience Statistics team at Eli Lilly and Company. She played a key role in the Advanced Analytics team to provide Bayesian education and statistical consultation at Eli Lilly. Dr. Natanegara is the chair of the cross industry-regulatory-academic DIA BSWG to ensure that Bayesian methods are appropriately utilized for design and analysis throughout the drug-development process. | Bayesian Applications in Pharmaceutical Development

GBP 44.99
1