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Skeletal Development and Repair - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Skeletal Development and Repair - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This second edition provides a comprehensive laboratory manual on skeletal development and skeletal repair research utilizing mouse models. Chapters provide methods and protocols on the most current and cutting-edge techniques in skeletal development and repair, histological, cellular, and molecular techniques. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Skeletal Development and Repair: Methods and Protocols-Second Edition aims to ensure successful results in the further study of this vital field.

DKK 967.00
1

Stem Cells and Tissue Repair - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Stem Cells and Tissue Repair - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume looks at a collection of stem cell and regenerative techniques used by both novice and expert scientists. Chapters cover topics such as tissue repaired by expansion and reprogramming; induced pluripotent stem cells driven in neuronal or vascular differentiation; using mesenchymal stem cells to derive skeletal muscle, osteoblasts, and spermatogonial cells; and the technique of monitoring the development of sub-organ microenvironments in the developing pancreas. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Stem Cells and Tissue Repair: Methods and Protocols, Second Edition is a valuable resource that provides readers with the latest descriptions and references for exploring this vast field in regenerative medicine.

DKK 967.00
1

Catheter Based Valve and Aortic Surgery - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Catheter Based Valve and Aortic Surgery - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This text provides a comprehensive, state-of-the-art review of catheter based approaches to valve and aortic diseases. The scope encompasses involve all the current and upcoming transcatheter aortic valve technologies as well as mitral, pulmonary and tricuspid valve technologies. Aortic diseases including transcatheter repair of descending aneurysms are included and the upcoming technologies designed to repair aortic dissections, traumatic injury, and ascending arch stent repair are highlighted. Catheter Based Valve and Aortic Surgery will be a useful tool for cardiac and vascular surgeons, interventional cardiologists, general cardiologists, and clinicians and researchers with an interest in these exciting new developments in structural heart and vascular diseases.​

DKK 676.00
1

Cartilage Imaging - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Cartilage Imaging - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This authoritative book provides state-of-the-art practices and new developments in the imaging of cartilage, associated pathologies, and repair procedures. With a main focus on MRI, major advances in cartilage imaging are put into clinical context relevant for radiologists, rheumatologists, and orthopedic surgeons. International experts provide their insights on cartilage pathologies associated with such conditions as osteoarthritis, osteochondral trauma, and cartilage repair. Morphological MRI techniques are outlined, including new sequences and high field imaging. Molecular imaging techniques able to characterize the biochemical composition of the cartilage matrix are discussed, such as T2 relaxation time, T1rho, and dGEMRIC methods. The first book of its kind, Cartilage Imaging: Significance, Techniques, and New Developments encompasses the full scope of knowledge in this rapidly evolving field. Identifying key techniques for characterizing disease processes as well as objectively and quantitatively evaluating the results of therapy, this outstanding resource is of benefit to all physicians interested in assessing cartilage disease and repair.

DKK 861.00
1

Redo Cardiac Surgery in Adults - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Redo Cardiac Surgery in Adults - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Redo cardiac surgeries are challenging cases with a myriad of influential factors, ranging from the patient''s pathology to the whimsy of the previous surgeon. Redo Cardiac Surgery in Adults, 2nd Edition clearly outlines practical approaches, surgical techniques, and management of associated conditions such as perioperative stroke and acute kidney function. It covers the spectrum of redo cardiac operations, including coronary artery bypass, mitral valve repair, reoperation for prosthetic mitral valve endocarditis, aortic arch reoperation, descending and thoracoabdominal aortic reoperation, and reoperations following endovascular aortic repair. All redo cardiac surgeries present a complex array of challenges beyond what the original procedure demands. This book, written by an outstanding group of prominent physicians, will give the reader the knowledge and tools to approach these cases with confidence.

DKK 861.00
1

Statistical Quality Control for the Food Industry - Merton R. Hubbard - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Statistical Quality Control for the Food Industry - Merton R. Hubbard - Bog - Springer-Verlag New York Inc. - Plusbog.dk

If an automobile tire leaks or an electric light switch fails, if we are short­ changed at a department store or erroneously billed for phone calls not made, if a plane departure is delayed due to a mechanical failure - these are rather ordinary annoyances which we have come to accept as normal occur­ rences. Contrast this with failure of a food product. If foreign matter is found in a food, if a product is discolored or crushed, if illness or discomfort occurs when a food product is eaten-the consumer reacts with anger, fear, and sometimes mass hysteria. The offending product is often returned to the seller, or a disgruntled letter is written to the manufacturer. In an extreme case, an expensive law suit may be filed against the company. The reaction is almost as severe if the failure is a difficult-to-open package or a leaking container. There is no tolerance for failure of food products. Dozens of books on quality written for hardware or service industries discuss failure rates, product reliability, serviceability, maintainability, warran­ ty, and repair. Manufacturers in the food industry cannot use these measure­ ments: food reliability must be 100%, failure rate 0%. Serviceability, main­ tainability, warranty, and repair are meaningless terms to food processors.

DKK 663.00
1

DNA Damage Responses - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

DNA Damage Responses - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume provides detailed methods and key approaches used to m echanistically study DNA damage, as well as the factors involved in the damage response. Chapters guide readers through proteomics and biophysical approaches, analyzing protein function, quantifying DNA replication dynamics and nucleic acid base damage, as well as biochemical reconstitution of key pathways involved in DNA repair. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, DNA Damage Responses: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.

DKK 986.00
1

Knee Arthroscopy - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Knee Arthroscopy - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Arthroscopic procedures are a welcome alternative to total joint replacement and, with millions of procedures performed each year, the field of knee arthroscopy is rapidly advancing as instrumentation and applications are developed and refined. Knee Arthroscopy is a technique-oriented "how-to" guide, written by internationally renowned authorities who present the latest advances in the field in a clear, step-by-step format. Chapters discuss issues such as meniscal transplantation, articular cartilage repair, anterior cruciate ligament treatment and other surgical procedures, and the text is supplemented throughout by case studies, clinical pearls and a wealth of illustrations. Knee Arthroscopy is a comprehensive reference sure to be invaluable for anyone involved in care of the knee, from the general orthopedist to the most skilled knee surgeon.

DKK 800.00
1

Autonomous Robot Vehicles - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Autonomous Robot Vehicles - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Autonomous robot vehicles are vehicles capable of intelligent motion and action without requiring either a guide or teleoperator control. The recent surge of interest in this subject will grow even grow further as their potential applications increase. Autonomous vehicles are currently being studied for use as reconnaissance/exploratory vehicles for planetary exploration, undersea, land and air environments, remote repair and maintenance, material handling systems for offices and factories, and even intelligent wheelchairs for the disabled. This reference is the first to deal directly with the unique and fundamental problems and recent progress associated with autonomous vehicles. The editors have assembled and combined significant material from a multitude of sources, and, in effect, now conviniently provide a coherent organization to a previously scattered and ill-defined field.

DKK 663.00
1

Skeletal Muscle Stem Cells - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Skeletal Muscle Stem Cells - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume looks at the latest technologies and methods--combined with new genetic tools available in animal models--used in this constantly evolving field. The chapters in this book are organized into three sections: Section one covers muscle stem cells and progenitor cells; Section Two discusses animal models for muscle stem cells and regeneration; and Section Three explores bioinformatics and imaging analysis for muscle stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Skeletal Muscle Stem Cells and Regeneration: Methods and Protocols is a valuable tool for all researchers looking to expand their knowledge on skeletal muscle growth, repair, degeneration, aging, and regenerative medicine.

DKK 967.00
1

CRISPR-Cas Methods - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

CRISPR-Cas Methods - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume details the fundamentals of the CRISPR-Cas system, and its protocols illustrate advances in CRISPR-Cas techniques for efficient genome editing. Introductory chapters provide a wide horizon of CRISPR/Cas-based methods and applications. Additional chapters guide readers through HDR-mediated editing, sgRNA design, the step-by-step procedure of multiplex adenine base editing experiments in rice, generating mutants for rice, wheat, Brachypodium, Barley, Flax, and Phytophthora, visual screening of mutants, gene deletion (knock-out), tagging (knock-in) in mammalian cells, the cloning-free (DNA-free) technique, cell-penetrating peptides, generating a genome-edited banana, and nuclear genome editing of Chlamydomonas employing CRISPR-Cpf1 combined with a single-stranded DNA (ssODN) repair template. Authoritative and cutting-edge, CRISPR-Cas Methods aims to assist researchers who are new to the field and are aiming to learn how best to adopt this technology for a particular organism.

DKK 967.00
1

Osteoporosis and Osteoarthritis - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Osteoporosis and Osteoarthritis - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This detailed second edition provides key updates on well-established methods as well as coverage of recently emerging sophisticated techniques and methods that are essential for an in-depth and state-of-the-art understanding of skeletal development and homeostasis and the pathological mechanisms that cause skeletal degeneration. The first half of the book examines cell and molecular biological aspects of osteoarthritis and osteoporosis, while the remainder of the collection focuses on in vivo models of skeletal tissue injury, degeneration, and repair. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Osteoporosis and Osteoarthritis, Second Edition aims to assist investigators concerned with research topics broadly related to osteoporosis, osteoarthritis, intervertebral disc degeneration, as well as other musculoskeletal disorders.

DKK 884.00
1

Congenital Heart Disease - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Congenital Heart Disease - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Procedure and Techniques The aortic valve in these patients is most often The dilation can be approached from either a myxomatous and bicuspid with a single, fused retrograde or antegrade direction. Remember commissure and an eccentrically placed orifice, that critical AS is a case of millimeters-so you or unicuspid (dome-shaped). The valve annulus need to be meticulous. may be small for age, but there is evidence that following dilation even quite small annuli may grow to a normal or near normal dimension (1). Retrograde Approach Myxomatous valves may mature, as Myxo- tous pulmonary valves. Because there is a spec- This is the more common approach at Children''s trum to left-sided obstructive lesions, often the Hospital Boston since the production of l- first decision in many of these patients is whether profile balloons. Often the umbilical artery and they should have a valvotomy or a staged o- vein already have been cannulated, and may be ventricle repair.

DKK 884.00
1

The Mathematics of Juggling - Burkard Polster - Bog - Springer-Verlag New York Inc. - Plusbog.dk

The Mathematics of Juggling - Burkard Polster - Bog - Springer-Verlag New York Inc. - Plusbog.dk

As a juggler the author likes to finish his performances with a stunt that combines props and techniques from a variety of juggling disciplines. Imagine him idling on a giraffe unicycle, while balancing a spinning basketball on a mouth stick, and toss-juggling a sword, a toilet plunger, and a rubber chicken. As a mathematician he is also interested in the treasure trove of beautiful mathematics used to model the different activities in a juggler''s repertoire. In this book he provides an intellectually stimulating collection of mostly self-contained mathematical essays that introduce the reader to many elegant results and techniques from a wide range of mathematical disciplines such as combinatorics, graph theory, knot theory, mechanics, differential equations, control theory, and robotics. "The Mathematics of Juggling" is the first comprehensive account summarizing and expanding the results in the literature on juggling tricks and skills, as well as the mathematics behind these tricks and skills. Anybody who is not put off by the word "mathematics" in the title of this book should have a good time reading it.

DKK 418.00
1

Transesophageal Echocardiography - Norbert P. De Bruijn - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Transesophageal Echocardiography - Norbert P. De Bruijn - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Almost every effort in the care of patients with heart disease begins with some description of disordered physiologic performance or mor­ phologic anatomy. Since the early work of Edler and Hertz in 1954, echocardiographic methods have grown in importance and reliability for the diagnosis of many cardiac disorders. The placement of a maneuverable transducer on the tip of a modified endoscope is the result of relatively recent technologic advances. The transesophageal approach is now a reality for obtaining new information from ultra-sonic images of a beating human heart. Since images obtained by transesophageal echo cardiography are uniformly of excellent quality, it extends the diagnostic potential of echocardiography to the patient who is difficult to image from the conventional chest wall approach. More importantly, transesophageal echocardiography provides a means to acquire useful information in new situations, such as the operating room. When this imaging modality is brought to patients undergoing surgical procedures, surgeons and anesthesiologists have a ready means for assessing cardiac performance during anesthesia, directing various surgical approaches and immediately evaluating the results of surgical repair. Transesophageal echocardiographic techniques represent a major vi vii advance in the care of patients with cardiovascular disease. Never before has there been a means to acquire such important information about the heart during an operative intervention. New questions are being asked and new answers are at hand.

DKK 434.00
1

Stable Fixation of the Hand and Wrist - Alan E. Freeland - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Stable Fixation of the Hand and Wrist - Alan E. Freeland - Bog - Springer-Verlag New York Inc. - Plusbog.dk

In the past, conservative (or nonoperative) treatment of fractures of the hand has been the rule and severe and multiple fractures usually did not receive surgical atten­ tion. There are probably several reasons why this is so. Rarely did these fractures threaten life; they usually healed rapidly; and after immobilization, hand pain usually subsided. At the same time, intraarticular fractures frequently were unstable and often displaced and attempts to correct deformity were considered difficult to achieve. As a result, the ultimate joint motion in many cases was limited. It can fairly be said that decisions and techniques regarding internal fixation of small joints and bones were not known to most surgeons. Although the history of internal fixation is not extensive, there have been some exciting events. In the 16th century gold plates were used to repair cleft palates. Later, the Chinese employed wire loop sutures to correct difficult fractures. In the 18th century silver cerclage wires were used to achieve fixation and promote early bone healing. Although these fracture treatments occasionally proved successful, more frequently they did not and they never enjoyed wide acceptance. Doctors Alan Free­ land, Michael Jabaley, and James Hughes have described this history of bone fixation in a manner that is both colorful and educational and they have managed to extract the essential features that lend continuity to the story of the development of internal fixation.

DKK 663.00
1

The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

In this volume are collected 30 papers, 9 round table discus­ sions and 11 communications presented at the ASI Course on "The use of human cells for the evaluation of risk from physical and chemical agents", sponsored by NATO and organized by ENEA. The aim of the Course was to present different scientific ap­ proaches and technical advices in order to get dose-effect relation­ ships which are the basis for risk evaluation. The scientific back­ ground which is behind this approach was extensively discussed. Emphasis has been given to the use of human cells or human data in order to attempt to have a correct and realistic evaluation of the damage in humans. There are many criticisms on the use of animal data for human risk evaluation because of differences between species and between strains within the same species: differences in metabolism, activa­ tion processes and DNA repair ability makes uncertain the extrapola­ tion of animal data to humans. Also data obtained using specific strains or highly inbred strains in order to reduce the variance are not applicable due to the heterogeneity of the human population connected with individual responses. In this respect only the use of human cells enable us to detect the individual variability and to identify sensitive subpopu­ lations that would be at greater risk. My appreciation to Pieranita and Alberto Castellani for the as­ sistance during the meeting and to Giuseppe Biondi for his help in some of the editorial work.

DKK 434.00
1

The Reflection of Life - A. H. Louie - Bog - Springer-Verlag New York Inc. - Plusbog.dk

The Reflection of Life - A. H. Louie - Bog - Springer-Verlag New York Inc. - Plusbog.dk

​​​A. H. Louie’s The Reflection of Life: Functional Entailment and Imminence in Relational Biology is a continuation of the exploratory journey in relational biology which began with his 2009 monograph More Than Life Itself: A Synthetic Continuation in Relational Biology. The theme of his first book was ‘What is life?’; the theme of this sequel is “How do two life forms interact?” Biology is a subject concerned with organization of relations. Relational biology is the approach that advocates ‘function dictates structure”, rather than ‘structure implies function’. It is mathematics decoded into biological realizations. The book demonstrates some of the powers of the approach of relational biology, and illustrates how pertinent problems in biology can be better addressed this way. In the first volume the theory was developed by using partially ordered sets, lattices, simulations, models, Aristotle’s four causes, graphs, categories, simple and complex systems, anticipatory systems, and metabolism-repair [(M,R)-] systems. Here in the second volume, these tools are expanded to employ set-valued mappings, adjacency matrices, random graphs, and interacting entailment networks. The theory of set-valued mappings culminates in the imminence mapping, which equips the further investigation of functional entailment in complex relational networks. Imminence in (M,R)-networks that model living systems addresses the topics of biogenesis and natural selection. Interacting (M,R)-networks with mutually entailing processes serve as models in the study of symbiosis and pathophysiology. The formalism also provides a natural framework for a relational theory of virology and oncology. This book will serve researchers and graduate students in mathematics and biology.

DKK 487.00
1