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The EU's Response to Brexit - Brigid Laffan - Bog - Springer International Publishing AG - Plusbog.dk

The EU's Response to Brexit - Brigid Laffan - Bog - Springer International Publishing AG - Plusbog.dk

This book is the first detailed analysis of how the EU responded to Brexit. It is an important reference point for future studies of the Brexit negotiations. The authors conducted in-depth interviews with key institutional players in Brussels and in several member states to document how the EU handled the first-ever exit of one of its members. The Brexit shock came at a time when the EU had barely recovered from the Euro crisis and was struggling to manage an unprecedented inflow of refugees. The immediate fear was that Brexit might be the final straw that broke the camel ''s back. Eurosceptics were jubilant, and Europhiles were distraught. In reality, the EU reacted to Brexit with resolve and a determination to protect the polity. The book argues that getting the process right was crucial. The EU mobilised its collective capacity to negotiate effectively and with one voice.

DKK 986.00
1

Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents - - Bog - Springer International Publishing AG - Plusbog.dk

Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents - - Bog - Springer International Publishing AG - Plusbog.dk

Thisbook is a comprehensive resource on psychotropic medications, detailing thelatest methods for defining their characteristics, their use in differentpatient populations, and drug-drug interactions; an important collection ofinformation forclinicians, students, researchers, and members of thepharmaceutical industry alike. Thefirst section provides the foundational principles of these drugs. Mathematicalmodeling of parameters that affect their entryto,and exit from, the centralnervous system (CNS) compartment are presented on an individual basis and thenapplied to target populations with specific disease states. Methods andcharacteristics that inform the transfer of these drugs from the laboratorybench to use in patient care are discussed, including imaging techniques,genetics and physiological barriers, such as the blood-brain barrier. The secondsection describes the characteristics of specific agents,nominally arrangedintodifferent therapeutic categories and with reference crossover use indifferent disease states. The pharmacologic characteristics of different drugformulations are explored in the context of their ability to improve patientadherence. The third section focuses on drug-drug interactions.Psychotropic medicationsfrom different categories are frequently prescribed together,or alongsidemedications used to treat comorbid conditions, and the information provided isdirectly relevant to the clinic, as a result. Theclinical application of pharmacokinetics and pharmacodynamics of CNS agents hasmade significant progress over the past 50 years and new information is reportedby numerous publications in psychiatry, neurology, and pharmacology.Ourunderstanding of the interrelationship between these medications, receptors,drug transporters, as well as techniques for measurement and monitoring theirinteractions,isfrequently updated. However, with information presented on ahost of different platforms, and in different formats, obtaining the fullpicture can be difficult. This title aims to collate this information into asingle source that can be easily interpreted and applied towards patient careby the clinical practitioner, and act as a reference for all others who have aninterest in psychopharmacological agents.

DKK 967.00
1

Potential Functions of Random Walks in Z with Infinite Variance - Kohei Uchiyama - Bog - Springer International Publishing AG - Plusbog.dk

Potential Functions of Random Walks in Z with Infinite Variance - Kohei Uchiyama - Bog - Springer International Publishing AG - Plusbog.dk

This book studies the potential functions of one-dimensional recurrent random walks on the lattice of integers with step distribution of infinite variance. The central focus is on obtaining reasonably nice estimates of the potential function. These estimates are then applied to various situations, yielding precise asymptotic results on, among other things, hitting probabilities of finite sets, overshoot distributions, Green functions on long finite intervals and the half-line, and absorption probabilities of two-sided exit problems. The potential function of a random walk is a central object in fluctuation theory. If the variance of the step distribution is finite, the potential function has a simple asymptotic form, which enables the theory of recurrent random walks to be described in a unified way with rather explicit formulae. On the other hand, if the variance is infinite, the potential function behaves in a wide range of ways depending on the step distribution, which the asymptotic behaviour of many functionals of the random walk closely reflects. In the case when the step distribution is attracted to a strictly stable law, aspects of the random walk have been intensively studied and remarkable results have been established by many authors. However, these results generally do not involve the potential function, and important questions still need to be answered. In the case where the random walk is relatively stable, or if one tail of the step distribution is negligible in comparison to the other on average, there has been much less work. Some of these unsettled problems have scarcely been addressed in the last half-century. As revealed in this treatise, the potential function often turns out to play a significant role in their resolution. Aimed at advanced graduate students specialising in probability theory, this book will also be of interest to researchers and engineers working with random walks and stochastic systems.

DKK 519.00
1