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Impact of Oxidative Stress on Diabetes Mellitus & Inflammatory Bowel Diseases - Konrad Siala - Bog - Nova Science Publishers Inc - Plusbog.dk

Impact of Oxidative Stress on Diabetes Mellitus & Inflammatory Bowel Diseases - Konrad Siala - Bog - Nova Science Publishers Inc - Plusbog.dk

Formation of reactive oxygen species (ROS) is a natural process during oxidative metabolism. ROS play an important role not only in pathological processes of human organism as usually presented but less attention is paid to their proper important role in cell signalling, biosynthesis or non-specific anti-infectious defence. Overproduction of ROS during numerous pathological situations in presence of insufficient antioxidant protection leads to substantial oxidative changes of lipids, proteins, sugars, and also DNA. Protection against ROS is assured by different extracellular or intracellular antioxidant mechanisms as studied during last decades. Antioxidant enzymes rectifying the oxidative damage are studied with regard to their different activities and usefulness in body protection. Their genetic polymorphisms are certainly involved in different response to oxidative stress. Special attention should be devoted to the topic of oxidative nuclear and mitochondrial DNA damage and its restoring via DNA repair process, especially base excision repair (BER). A large scale of antioxidant enzymes is involved in correction of DNA oxidative damage. Natural trend of worsened DNA repair is usually associated with aging. Other pathologies related with deficient DNA repair are susceptibility to carcinogenesis (lack of apoptosis control) or degenerative diseases. Oxidative stress is involved in the pathophysiology of diabetes mellitus (DM -- oxidative stress of mainly metabolic origin) and inflammatory bowel diseases (IBD -- oxidative stress of mainly inflammatory origin). In spite of confirmed OS in DM or IBD, the substantial information about the intensity of DNA repair and its possible relationship to the disease course and development of chronic complications is missing. The author pilot studies completed both in adult and paediatric patients with DM or IBD confirmed an increased oxidative stress as well as oxidative DNA damage examined with comet assay. The surprising findings were ascertained in intensity of DNA repair (analysed with modified comet assay).

DKK 890.00
1

What Doesn't Kill Us, Makes Us Stronger - Irina Milisav - Bog - Nova Science Publishers Inc - Plusbog.dk

Extensor Tendons - - Bog - Nova Science Publishers Inc - Plusbog.dk

Abdominal Aortic Aneurysms - David S Molony - Bog - Nova Science Publishers Inc - Plusbog.dk

Highway Bridge Replacement - Jun Huan - Bog - Nova Science Publishers Inc - Plusbog.dk

Highway Bridge Replacement - Jun Huan - Bog - Nova Science Publishers Inc - Plusbog.dk

Protein Engineering - - Bog - Nova Science Publishers Inc - Plusbog.dk

Tumor Suppressor Genes in Breast Cancer - Marc Lacroix - Bog - Nova Science Publishers Inc - Plusbog.dk

Stem Cells & Cartliage Tissue Engineering Approaches to Orthopaedic Surgery - Timothy E Hardingham - Bog - Nova Science Publishers Inc - Plusbog.dk

To Own or Lease Solar Installations - - Bog - Nova Science Publishers Inc - Plusbog.dk

Water Infrastructure - Albert Engel - Bog - Nova Science Publishers Inc - Plusbog.dk

Concepts of Periodontal Regeneration & Regenerative Medicine - Mena Soory - Bog - Nova Science Publishers Inc - Plusbog.dk

Pioneering Human Myoblast Genome Therapy - Peter K Law - Bog - Nova Science Publishers Inc - Plusbog.dk

Pioneering Human Myoblast Genome Therapy - Peter K Law - Bog - Nova Science Publishers Inc - Plusbog.dk

Human Myoblast Genome Therapy (HMGT) is a platform technology of cell transplantation, nuclear transfer, and tissue engineering. Myoblasts are differentiated, immature cells destined to become muscles. Myoblasts cultured from muscle biopsy survive, develop and function to revitalise degenerative muscles upon transplantation. Transplant injury activates regeneration of host myofibers that fuse with the injected myoblasts, sharing their nuclei in a common gene pool of the syncytium. Thus, through nuclear transfer and complementation, human genome can be transferred into muscles of genetically-ill patients to achieve phenotype repair. Myoblasts are safe and efficient universal gene transfer vehicles endogenous to muscles that constitute 50% of the body. Myoblasts fuse among themselves to form new myofibres. Patients take only 2-month cyclosporine to immunosuppress allograft rejection because myofibres do not express MHC-1 antigens. The first correction of human gene defect was published in the Lancet on July 14, 1990 when the therapeutic protein dystrophin was found in the myoblast-injected muscle of a Duchenne muscular dystrophy (DMD) patient. Results over 280 HMGT procedures on MD subjects in the past 15 years demonstrated absolute safety. Myoblast-injected DMD muscles showed improved histology. Strength increase at 18 months post-operatively averaged 123%. FDA-approved clinical trials progressed unto Phase III in USA with direct cost recovery. Heart muscle degeneration is the leading cause of human debilitation and death.

DKK 534.00
1

Insomnia - Sandy Sacre - Bog - Nova Science Publishers Inc - Plusbog.dk

Ulcers - - Bog - Nova Science Publishers Inc - Plusbog.dk

Ulcers - - Bog - Nova Science Publishers Inc - Plusbog.dk

An ulcer is the result of an imbalance between aggressive and defensive factors. The pathology of ulcer is complex and may involve overproduction of acid or pepsin, inadequate mucosal defence, reflux of bile and pancreatic juice into stomach. Peptic ulcer is a classical example of the biopsychosocial model of disease and like most diseases, it has a multifactorial origin. Furthermore, peptic ulcer disease (PUD) is one of the common disorders affecting the digestive system. The lifetime risk of ulcer is 5-10% in developed countries. This book examines the psychosocial risk factors for developing peptic ulcers. It is shown that PUD occurs more frequently among individuals with anxiety and depressive disorders. The use of a fibrinogen- and thrombin-coated collagen patch for a perforated peptic ulcer is researched as a method to reduce morbidity and mortality rates. Through the application of such a device, previously used in hepatic surgery, a new and simple modification to the standard technique may improve the seal of the traditional repair, has no complications and makes the overall operation faster. In addition to peptic ulcers, the aetiology, diagnosis and treatment of gastric and skin ulcers are explored in this book, including the four most common etiologies that account for the large majority of skin ulcers in the elderly, the prevention and treatment of pressure ulcers and the results of research done on opical opioid therapy in treating pain from ulcers.

DKK 1132.00
1

Cardiac Wellness - Lawrence A Decker - Bog - Nova Science Publishers Inc - Plusbog.dk

DKK 232.00
1

Ribonucleotide Reductase Family - Margareta Sahlin - Bog - Nova Science Publishers Inc - Plusbog.dk

Ribonucleotide Reductase Family - Margareta Sahlin - Bog - Nova Science Publishers Inc - Plusbog.dk

Ribonucleotide reductase (RNR), a universal enzyme present in essentially all living cells and organisms, has a central role in DNA replication and repair by catalysing production of deoxyribonucleotides from the corresponding ribonucleotides. Three major classes of RNRs are known, differing in their cofactor requirements: class I RNRs (with subclasses Ia and Ib) carry a stable tyrosyl radical and are oxygen-dependent, class II RNRs require the vitamin B12 cofactor 5''-deoxyadenosylcobalamin and are oxygen-independent, and class III RNRs carry a stable glycyl radical and are oxygen-sensitive. Despite these differences, all classes have a similar reaction mechanism and the same highly specific catalytic core structure, indicating that they evolved from a common ancestor. Biochemical studies of RNRs from selected model organisms in combination with the vast number of deduced RNR sequences from publicly available complete genomic sequences show that whereas eukaryotes and their viruses with few exceptions contain only class Ia RNRs, all three major RNR classes are found among prokaryotes and bacteriophages and quite often one organism encodes more than one class of RNR. They are compiled in an open access database, called RNRdb for Ribonucleotide Reductase database that is available at http://rnrdb.molbio.su.se. RNRs are produced in a strictly controlled way depending upon growth phase and environmental cues. The authors describe a comprehensive summary of how the expression of RNR genes is regulated in several eubacterial organisms and in yeast. Due to RNR''s importance for the realisation of DNA replication, it has been recognised as a possible target for antiproliferative therapy. The authors present a comprehensive summary of RNR-specific inhibitors that have reached clinical trials and/or are currently used in clinical therapy.

DKK 534.00
1

Circadian Clock - - Bog - Nova Science Publishers Inc - Plusbog.dk

Circadian Clock - - Bog - Nova Science Publishers Inc - Plusbog.dk

In this collection, the authors review temporal control of tissue homeostasis and repair by the circadian system. The molecular regulation of circadian timing has been well-characterized in several species as a highly conserved transcriptional feedback loop that maintains roughly 24-hour cellular periodicity. A current challenge is determining how the outputs of the master clock affect peripheral oscillators and numerous biological processes. A subsequent study seeks a more detailed understanding of the physiology and molecular mechanism underlying circadian changes in the plasma of glucose, which might allow for the identification of novel targets for the developing therapeutic approached to the diabetes and obesity diseases. Procambarus acanthophorus, a burrower crayfish, follows a nocturnal circadian rhythm due to the way it spends long periods of time building tunnels to reach the water table during the dry season. Therefore, it follows that this species must have a close relationship with soil. The authors suggest that soil might be an ecological factor with high perceived value, influencing ecological aspects, and physiological functions such as growth, reproduction, and organization of the circadian system. The genes involved in the maintenance of circadian rhythm and its impact on the immunological system are described as disruption of the circadian rhythm leads to significant alterations of the organism and is associated with several biological responses. In the concluding review, some of the most useful characteristics of zebrafish for studying the molecular, cellular, and behavioral aspects of the circadian clock system are described. Zebrafish have been established as an attractive vertebrate model for the examination of light signaling pathways and their impact on the cellular clock because zebrafish cellular clocks have an unusual attribute of being directly light responsive. Additionally, the molecular components of the mammalian and zebrafish cellular clocks are highly similar.

DKK 1034.00
1

Student Grade Retention - - Bog - Nova Science Publishers Inc - Plusbog.dk

Student Grade Retention - - Bog - Nova Science Publishers Inc - Plusbog.dk

During the 1980''s, grade retention increased as school districts instituted policies that linked standardised test scores to student promotion and placement decisions. However, research has found grade retention does not improve student learning. Enforcement of promotional standards at every grade level is expected to ensure the competency of high school graduates and lower student dropout rates. Despite such belief, studies show "flunking" students are traumatic and increases student dropout. Researchers found a relationship between grade retention and high school dropout rates. Dropouts are five times more likely to have repeated a grade than high school graduates. In three studies involving 20,000 to 80,000 students, retained students were 20 to 30 percent more likely to dropout of school. Moreover, African American males with below average achievement had a 45% chance of dropping out of school; while retained African American males with identical achievement scores have a 75% chance of dropping out of school. While retention may serve as a "stick" for students to perform better; usually retained students frustratingly repeat the previous year''s instruction, and ultimately disengage from school. To address student grade retention, more funding is needed to support schools implement alternative programs to address students'' academic needs and decrease the pernicious practice of student retention. Despite such research, student grade retention continues as a common practice within our nation''s schools. However, student grade retention from the perspectives of parents have been hushed; and practical recommendations and programs to decrease student grade retention while increasing student achievement are still needed. In this book, the voices of parents and their children experiences are presented. Hearing their voices provides unique insight on action steps we (all educational stakeholders) can take to better educate all students. Additionally, innovative practical programs that work and could be replicated in schools are discussed. This book is a must read for administrators, educators, parents and related practitioners who seek "out of the box" ideas to better educate our students, particularly those in urban schools.

DKK 722.00
1

DNA Methylation in Plants - Vasili V Ashapkin - Bog - Nova Science Publishers Inc - Plusbog.dk

DNA Methylation in Plants - Vasili V Ashapkin - Bog - Nova Science Publishers Inc - Plusbog.dk

A high degree of nuclear DNA (nDNA) methylation is a specific feature of plant genomes, they do contain 5-methylcytosine (m5C) and N6-methyladenine (m6A). More than 30% m5C is located in CNG sequences. Specific changes in DNA methylation accompany the entire life of a plant starting from seed germination up to the death programmed or induced by various agents and factors of biological or abiotic nature. Modulation of DNA methylation is one of the possible modes of the hormonal action in plant. DNA methylation in plants is species-, tissue-, organelle- and age-specific; it is involved in the control of all genetic functions including transcription, replication, DNA repair, gene transposition and cell differentiation. DNA methylation is engaged in gene silencing and parental imprinting, it controls transgenes and foreign DNA. Plants have much more complicated and sophisticated system of the multi-component and sometimes even conjugated genome (nuclear DNA) methylations compared with animals; besides, unlike animals, they have the plastids with their own unique DNA modification system that may control plastid differentiation and functioning; DNA methylation in plant mitochondria is performed in other fashion compared with it in nuclei. The nuclear DNA methylation system is controlled by three major families of cytosine DNA-methyltransferase genes, at least. In contrast to animals the inactivation of major maintenance methyltransferase MET1 (similar to animal Dnmt1) has no significant consequences for plant survival. Other plant cytosine DNA-methyltransferases have no analogs in animals. Some of them (DRM) are responsible for de novo DNA methylation including asymmetric sequences. Plant gene may be methylated at both adenine and cytosine residues; specific adenine DNA-methyltransferase was described. Adenine DNA methylation may influence cytosine modification and vice versa. Anyway, two different systems of the genome modification based on methylation of adenines and cytosines coexist in higher plants. The specific endonucleases discriminating between methylated and unmethylated DNA are present in plants. Thus, plants may have restriction-modification system. There are peculiar complicated controls for growth and development by DNA methylations in plants; they are well co-ordinated with other epigenetic signals modulating chromatin organisation.

DKK 405.00
1