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Vaccine Safety Forum - Institute Of Medicine - Bog - National Academies Press - Plusbog.dk

Vaccine Safety Forum - Institute Of Medicine - Bog - National Academies Press - Plusbog.dk

On November 6, 1995, the Institute of Medicine's Vaccine Safety Forum convened a workshop on detecting and responding to adverse events following vaccination. Workshop speakers and participants discussed the difficulties in detecting adverse events, current adverse events detection and response methods and procedures, suggestions for improving the means of detecting and responding to adverse events following vaccination, and future areas of research. This document represents a summary of that workshop.

DKK 305.00
1

Addressing Treatment Resistance in the Development of Cancer Immune Modulator Therapeutics - Development Forum On Drug Discovery - Bog - National

Addressing Treatment Resistance in the Development of Cancer Immune Modulator Therapeutics - Development Forum On Drug Discovery - Bog - National

The use of immune modulator therapeutics, a type of immunotherapy enhancing the body immune system response to cancer, was perceived as the beginning of a new era in cancer care. While still important and frequently used, some of these therapeutics produce uneven response rates, disease resistance, and serious side effects. The National Academies National Cancer Policy Forum, in collaboration with the Forum on Drug Discovery, Development, and Translation, hosted a public workshop to discuss challenges related to immunotherapy treatment resistance, as well as potential policy opportunities to improve the development of immunotherapies for cancer treatment. Table of ContentsFront MatterProceedings of a WorkshopAppendix A: Statement of TaskAppendix B: Workshop Agenda

DKK 195.00
1

Adult Attention-Deficit/Hyperactivity Disorder - Forum On Neuroscience And Nervous System Disorders - Bog - National Academies Press - Plusbog.dk

Adult Attention-Deficit/Hyperactivity Disorder - Forum On Neuroscience And Nervous System Disorders - Bog - National Academies Press - Plusbog.dk

Attention deficit/hyperactivity disorder (ADHD) diagnosis and treatment among adults has increased over the past decade in the U.S. and globally. Evidence suggests adults with ADHD may be more likely to develop a substance use disorder, and there are concerns that nonmedical use of prescription stimulants could lead to misuse, overdose, or toxicity. In December 2023, The National Academies Forum on Drug Discovery, Development, and Translation and Forum on Neuroscience and Nervous System Disorders held a public workshop to examine the diagnosis and treatment of adults with ADHD and explore the challenges and opportunities for the development of new therapeutics. The workshop was supported, in part, through a grant (PAR-23-072) from the Center for Drug Evaluation and Research at the FDA. Table of ContentsFront Matter1 Introduction2 ADHD Diagnosis and Treatment in the United States3 Impact of Misdiagnosis, Bias, and Stigma4 Shared Decision-Making5 Balancing Risks and Benefits of ADHD Treatment for Adults6 Potential Strategies and Implications for Drug Development7 Public Health Considerations and Harm Reduction StrategiesReferencesAppendix A: Workshop AgendaAppendix B: Biographical Sketches of the Workshop Planning Committee, Speakers, Panelists, and Staff

DKK 208.00
1

Toward a Common Research Agenda in Infection-Associated Chronic Illnesses - Forum On Neuroscience And Nervous System Disorders - Bog - National

Toward a Common Research Agenda in Infection-Associated Chronic Illnesses - Forum On Neuroscience And Nervous System Disorders - Bog - National

The National Academies Forum on Microbial Threats and Forum on Neuroscience and Nervous System Disorders hosted a hybrid public workshop in June 2023 to explore opportunities to advance research and treatment of infection-associated chronic illnesses. The illnesses discussed in this workshop, including COVID-19, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), persistent or posttreatment Lyme disease syndrome (PTLDS), and multiple sclerosis (MS), share overlapping mechanisms and symptoms and have been inadequately researched. Recognizing these commonalities, speakers identified the need to advance research more comprehensively, translating to improved diagnostic and treatment options for patients across multiple conditions. Table of ContentsFront Matter1 Introduction2 Overview of Infection-Associated Chronic Illnesses3 Common Mechanistic Factors of Infection-Associated Chronic Illnesses4 Potential Research Priorities and Opportunities in Diagnostics5 Potential Research Priorities and Opportunities in Therapeutics6 Advancing Research for Infection-Associated Chronic Illnesses7 Considering Challenges and Opportunities in a Shared Research AgendaAppendix A: ReferencesAppendix B: Workshop Statement of TaskAppendix C: Workshop Agenda

DKK 201.00
1

Medical Countermeasures Dispensing - Forum On Medical And Public Health Preparedness For Catastrophic Events - Bog - National Academies Press -

Medical Countermeasures Dispensing - Forum On Medical And Public Health Preparedness For Catastrophic Events - Bog - National Academies Press -

During public health emergencies such as terrorist attacks or influenza outbreaks, the public health system's ability to save lives could depend on dispensing medical countermeasures such as antibiotics, antiviral medications, and vaccines to a large number of people in a short amount of time. The IOM's Forum on Medical and Public Health Preparedness for Catastrophic Events held a workshop on November 18, 2009, to provide an overview of current threats, recent progress made in the public health system for distributing and dispensing countermeasures, and remaining vulnerabilities.

DKK 208.00
1

CNS Clinical Trials - Forum On Neuroscience And Nervous System Disorders - Bog - National Academies Press - Plusbog.dk

CNS Clinical Trials - Forum On Neuroscience And Nervous System Disorders - Bog - National Academies Press - Plusbog.dk

The Food and Drug Administration (FDA) now requires that all clinical trials for drugs that affect the central nervous system—including psychiatric drugs—are assessed for whether that drug might cause suicidal ideation or behavior. The Institute of Medicine's (IOM) Forum on Neuroscience and Nervous System Disorders hosted a meeting on June 26, 2009, to discuss the FDA's new policy and how to analyze best whether suicidal thoughts predict actual suicidal behavior in the near future. Table of ContentsFront MatterIntroduction1 Perspectives from the FDA, Academia, and Patients2 Data Collection and Optimization3 Data Analysis4 Partnerships, Opportunities, CollaborationAppendix A: ReferencesAppendix B: Workshop AgendaAppendix C: Workshop AttendeesAppendix D: Biographical Sketches of Invited Speakers

DKK 188.00
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Alternative Protein Sources - Food Forum - Bog - National Academies Press - Plusbog.dk

Alternative Protein Sources - Food Forum - Bog - National Academies Press - Plusbog.dk

Alternative protein sources, which can be derived from plant and animal cells or created by precision fermentation, can have health, environmental, socio-economic, and ethical impacts. With a variety of types of alternative proteins being developed and available on the market, consumers, regulatory agencies, manufacturers, and researchers are faced with many different considerations. The National Academies Food Forum hosted a workshop that took a multi-sector approach to explore the state of the science on alternative protein sources as they relate to issues around diet quality, nutrition, and sustainability. The workshop also examined how alternative protein food processing innovations can be balanced in a way that optimizes nutritional content, affordability, and accessibility. This Proceedings of a Workshop summarizes the discussions held during the workshop. Table of ContentsFront Matter1 Introduction2 Current Protein Challenges3 Implications for the Industry, Consumers, and Regulators4 Balancing Innovation in Alternative Protein Processing with Sustainability, Health, Affordability, and AccessibilityReferencesAppendix A: Workshop AgendaAppendix B: Acronyms and AbbreviationsAppendix C: Biographical Sketches of Workshop Speakers and Planning Committee Members

DKK 208.00
1

Multi-Center Phase III Clinical Trials and NCI Cooperative Groups - National Cancer Policy Forum - Bog - National Academies Press - Plusbog.dk

Multi-Center Phase III Clinical Trials and NCI Cooperative Groups - National Cancer Policy Forum - Bog - National Academies Press - Plusbog.dk

The NCI-sponsored cooperative groups have made important contributions to improving treatment for many types of cancer, including breast, ovarian, colorectal, and childhood cancers. Cooperative group research has been instrumental in establishing innovative treatments that improve outcomes and quality of life. Despite these successes, the Cooperative Group Program has faced a number of challenges that threaten its effectiveness. To address this problem, the National Cancer Policy Forum (NCPF) convened a workshop titled "Multi-Center Phase III Clinical Trials and NCI Cooperative Groups" in Washington, DC, on July 1-2, 2008. The purpose of the workshop was to outline the challenges that the public clinical cancer research enterprise faces, and to identify possible solutions to these challenges. Table of ContentsFront MatterIntroductionSession 1A: Organization of the NCI Clinical Trials SystemSession 1B: Lessons from Non-Cooperative Group Multi-Center Clinical TrialsSession 2: Barriers to Patient Recruitment and Physician ParticipationSession 3: Data Collection Standards and MonitoringSession 4: Costs of Cooperative Group Clinical TrialsSummary and Wrap-UpReferencesAbbreviations and AcronymsGlossaryAppendix A: Workshop AgendaAppendix B: Workshop SpeakersAppendix C: Letter from John Niederhuber, Director of the National Cancer Institute, to Members of the National Cancer Policy Forum

DKK 461.00
1

A Summary of the February 2010 Forum on the Future of Nursing - Institute Of Medicine - Bog - National Academies Press - Plusbog.dk

A Summary of the February 2010 Forum on the Future of Nursing - Institute Of Medicine - Bog - National Academies Press - Plusbog.dk

As the U.S. health care system continues to evolve, the role of nurses also needs to evolve. Nurses must strike a delicate balance among advancing science, translating and applying research, and caring for individuals and families across all settings. Preparing nurses to achieve this balance is a significant challenge. The education system should ensure that nurses have the intellectual capacity, human responsiveness, flexibility, and leadership skills to provide care and promote health whenever and wherever needed. Education leaders and faculty need to prepare nurses with the competencies they need now and in the future. They need to prepare nurses to work and assume leadership roles not just in hospitals, but in communities, clinics, homes, and everywhere else nurses are needed. On February 22, 2010 the Initiative on the Future of Nursing held the last public forum in a series of three at the University of Texas MD Anderson Cancer Center. This forum, which covered the education of nurses, consisted of three armchair discussions. Each discussion was led by a moderator from the committee and focused on three broad, overlapping subjects: what to teach, how to teach, and where to teach. The verbal exchange among the discussants and moderators, prompted by additional questions from committee members at the forum, produced a wide-ranging and informative examination of questions that are critical to the future of nursing education. Additionally, testimony presented by 12 individuals and comments made by members of the audience during an open microphone session provided the committee with valuable input from a range of perspectives. Table of ContentsFront Matter1 Introduction2 What to Teach3 How to Teach 4 Where to Teach5 TestimonyAppendix A ReferencesAppendix B Agenda Appendix C Speaker Biosketches

DKK 208.00
1

Ensuring Quality Cancer Care Through the Oncology Workforce - National Cancer Policy Forum - Bog - National Academies Press - Plusbog.dk

Ensuring Quality Cancer Care Through the Oncology Workforce - National Cancer Policy Forum - Bog - National Academies Press - Plusbog.dk

The American Society of Clinical Oncology (ASCO) predicts that by 2020, there will be an 81 percent increase in people living with or surviving cancer, but only a 14 percent increase in the number of practicing oncologists. As a result, there may be too few oncologists to meet the population's need for cancer care. To help address the challenges in overcoming this potential crisis of cancer care, the National Cancer Policy Forum of the Institute of Medicine (IOM) convened the workshop Ensuring Quality Cancer Care through the Oncology Workforce: Sustaining Care in the 21st Century in Washington, DC on October 20 and 21, 2008.

DKK 208.00
1

Early Interventions for Psychosis - Forum On Mental Health And Substance Use Disorders - Bog - National Academies Press - Plusbog.dk

Early Interventions for Psychosis - Forum On Mental Health And Substance Use Disorders - Bog - National Academies Press - Plusbog.dk

Studies show that people commonly have psychotic symptoms for over a year before receiving treatment. Reducing this duration is critical, because early treatment is strongly associated with better outcomes. The National Academies Forum on Mental Health and Substance Use Disorders hosted a workshop in July 2022 to examine the current evidence on short- and long-term outcomes for people at high risk for psychosis. Speakers explored potential policy solutions and strategies that are most effective for coordinated, early-intervention specialty services. This Proceedings document summarizes workshop discussions. Table of ContentsFront MatterProceedings of a WorkshopREFERENCESAPPENDIX A: STATEMENT OF TASKAPPENDIX B: WORKSHOP AGENDAAPPENDIX C: SPEAKER, MODERATOR, AND PLANNING COMMITTEE BIOGRAPHICAL SKETCHES

DKK 169.00
1

Providing Healthy and Safe Foods As We Age - Food Forum - Bog - National Academies Press - Plusbog.dk

Providing Healthy and Safe Foods As We Age - Food Forum - Bog - National Academies Press - Plusbog.dk

Does a longer life mean a healthier life? The number of adults over 65 in the United States is growing, but many may not be aware that they are at greater risk from foodborne diseases and their nutritional needs change as they age. The IOM's Food Forum held a workshop October 29-30, 2009, to discuss food safety and nutrition concerns for older adults. Table of ContentsFront MatterOverview1 Introduction2 Size and Demographics of Aging Populations3 Physiology and Aging4 Food Safety Concerns for Aging Populations5 Nutrition Concerns for Aging Populations6 Communicating with Aging Populations7 Future Challenges and Solutions to Providing Healthy and Safe Foods to Aging PopulationsReferencesAppendix A: Workshop AgendaAppendix B: Workshop ParticipantsAppendix C: Speaker, Moderator, and Panelist BiographiesAppendix D: Abbreviations and Acronyms

DKK 344.00
1

Transforming Clinical Research in the United States - Development Forum On Drug Discovery - Bog - National Academies Press - Plusbog.dk

Transforming Clinical Research in the United States - Development Forum On Drug Discovery - Bog - National Academies Press - Plusbog.dk

An ideal health care system relies on efficiently generating timely, accurate evidence to deliver on its promise of diminishing the divide between clinical practice and research. There are growing indications, however, that the current health care system and the clinical research that guides medical decisions in the United States falls far short of this vision. The process of generating medical evidence through clinical trials in the United States is expensive and lengthy, includes a number of regulatory hurdles, and is based on a limited infrastructure. The link between clinical research and medical progress is also frequently misunderstood or unsupported by both patients and providers. The focus of clinical research changes as diseases emerge and new treatments create cures for old conditions. As diseases evolve, the ultimate goal remains to speed new and improved medical treatments to patients throughout the world. To keep pace with rapidly changing health care demands, clinical research resources need to be organized and on hand to address the numerous health care questions that continually emerge. Improving the overall capacity of the clinical research enterprise will depend on ensuring that there is an adequate infrastructure in place to support the investigators who conduct research, the patients with real diseases who volunteer to participate in experimental research, and the institutions that organize and carry out the trials. To address these issues and better understand the current state of clinical research in the United States, the Institute of Medicine's (IOM) Forum on Drug Discovery, Development, and Translation held a 2-day workshop entitled Transforming Clinical Research in the United States. The workshop, summarized in this volume, laid the foundation for a broader initiative of the Forum addressing different aspects of clinical research. Future Forum plans include further examining regulatory, administrative, and structural barriers to the effective conduct of clinical research; developing a vision for a stable, continuously funded clinical research infrastructure in the United States; and considering strategies and collaborative activities to facilitate more robust public engagement in the clinical research enterprise. Table of ContentsFront Matter1 Introduction2 The State of Clinical Research in the United States: An Overview3 Challenges in Clinical Research4 Clinical Trials in Cardiovascular Disease5 Clinical Trials in Depression6 Clinical Trials in Cancer7 Clinical Trials in Diabetes8 Building a Robust Clinical Trials InfrastructureReferencesAppendix A AgendaAppendix B Participant Biographies

DKK 318.00
1

Managing Food Safety Practices from Farm to Table - Food Forum - Bog - National Academies Press - Plusbog.dk

Managing Food Safety Practices from Farm to Table - Food Forum - Bog - National Academies Press - Plusbog.dk

Legal regulations and manufacturers' monitoring practices have not been enough to prevent contamination of the national food supply and protect consumers from serious harm. In addressing food safety risks, regulators could perhaps better ensure the quality and safety of food by monitoring food production not just at a single point in production but all along the way, from farm to table. Recognizing the troubled state of food safety, the Institute of Medicine's (IOM) Food Forum met in Washington, DC, on September 9, 2008, to explore the management of food safety practices from the beginning of the supply chain to the marketplace. Table of ContentsFront MatterOverview1 Introduction2 Recent Outbreaks in Food Products: Lessons Learned from Past Experience3 The Complexities of Food Safety and Some Strategic Approaches Being Taken4 The Way Forward: Varying PerspectivesAppendix A: Workshop AgendaAppendix B: Workshop ParticipantsAppendix C: Speaker, Moderator, and Disscussant BiographiesAppendix D: Acronyms and Abbreviations

DKK 412.00
1

Transitioning to Sustainability Through Research and Development on Ecosystem Services and Biofuels - Science And Technology For Sustainability

Transitioning to Sustainability Through Research and Development on Ecosystem Services and Biofuels - Science And Technology For Sustainability

The National Research Council's Roundtable on Science and Technology for Sustainability hosted Transitioning to Sustainability through Research and Development on Ecosystem Services and Biofuels: The National Academies' 1st Federal Sustainability Research and Development Forum on October 2007. This book summarizes the discussions from the forum.

DKK 92.00
1

Nanotechnology and Oncology - National Cancer Policy Forum - Bog - National Academies Press - Plusbog.dk

Nanotechnology and Oncology - National Cancer Policy Forum - Bog - National Academies Press - Plusbog.dk

One way scientists are working to overcome challenges in cancer treatment and improve cancer care is through nanotechnology. Nanotechnology, engineered materials that make use of the unique physical properties, presents a new array of medical prospects that will revolutionize cancer prevention, diagnosis, and treatment practices. Giving new hope to patients, practitioners, and researchers alike, nanotechnology has the potential to translate recent discoveries in cancer biology into clinical advances in oncology. While public investments in nanotechnology for cancer continue to increase, medical products based on nanotechnology are already on the market. The National Cancer Policy forum held a workshop July 12-13, 2010, to explore challenges in the use of nanotechnology in oncology. Nanotechnology and Oncology evaluates the ongoing discussion on the role of nanotechnology in cancer as it relates to risk management, treatment, and regulatory policy. Assessments on nanomedicine and the physical properties of nanomaterials were presented during the workshop, along with an appraisal of the current status of research and development efforts. Table of ContentsFront Matter1 Introduction2 Uses of Nanotechnology in Oncology and Cancer Research3 Research and Development of New Cancer Nanomedicines - Challenges and Solutions4 Risks Associated with Nanotechnology5 Standards and Regulation6 Nanotechnology and the Public7 Additional Challenges8 Concluding RemarksReferencesAcronymsGlossaryA AgendaB Speaker and Planning Committee Biographies

DKK 221.00
1

Improving Intergroup Relations Among Youth - Forum On Adolescence - Bog - National Academies Press - Plusbog.dk

Improving Intergroup Relations Among Youth - Forum On Adolescence - Bog - National Academies Press - Plusbog.dk

On November 9-10, 1998, the Forum on Adolescence of the Board on Children, Youth, and Families, a cross-cutting initiative of the Institute of Medicine and the National Research Council of the National Academy of Sciences, convened a workshop entitled Research to Improve Intergroup Relations Among Youth. Held at the request of the Carnegie Corporation of New York, this workshop considered selected findings of 16 research projects that have focused on intergroup relations among children and adolescents; all 16 received funding from Carnegie Corporation of New York for their work on this issue. The funding of these projects was part of a larger research initiative supported by Carnegie Corporation of New York that sought to update and expand the knowledge, sources, and dynamics of racial and ethnic prejudice among youth, identifying approaches to foster intergroup understanding. Improving Intergroup Relations Among Youth is the summary of the workshop, which provided an opportunity to learn about the work and preliminary findings of the 16 projects. This report reviews the knowledge base regarding the effectiveness of interventions designed to promote peaceful, respectful relations among youth of different ethnic groups.

DKK 305.00
1

Exploring the Adoption of Implantable Brain Stimulation into Standard of Care for Central Nervous System Disorders - Forum On Neuroscience And Nervous

Exploring the Adoption of Implantable Brain Stimulation into Standard of Care for Central Nervous System Disorders - Forum On Neuroscience And Nervous

Implantable brain stimulation has had a profound impact on neuroscience research and the treatment of central nervous system disorders by allowing physicians to directly intervene in the pathological neural circuits of their patients. To explore the logistical, educational, and economic barriers to adopting this technology into regular use in clinical care, the National Academies Forum on Neuroscience and Nervous System Disorders hosted a public workshop in October 2023. Table of ContentsFront Matter1 Introduction and Background2 Crossing the Chasm: Lessons Learned Across Medical Technologies3 Perspectives from Those with Lived Experiences4 Patient Selection and Engagement5 Health Professional Education and Adoption6 Reimbursement and Other Economic Considerations7 Potential Next Steps to Move the Field ForwardAppendix A: ReferencesAppendix B: Workshop Agenda

DKK 195.00
1

Understanding the Role of the Immune System in Improving Tissue Regeneration - Forum On Regenerative Medicine - Bog - National Academies Press -

Understanding the Role of the Immune System in Improving Tissue Regeneration - Forum On Regenerative Medicine - Bog - National Academies Press -

The Forum on Regenerative Medicine of the National Academies of Sciences, Engineering, and Medicine convened a two-day virtual public workshop to address knowledge gaps in the understanding of promising approaches to manipulate the immune system and/or the regenerative medicine product to improve outcomes of tissue repair and regeneration in patients. The workshop, titled "Understanding the Role of the Immune System in Improving Tissue Regeneration," explored the role of the immune system in the success or failure of regenerative medicine therapies. Participants considered potential strategies to effectively "prepare" patients' immune systems to accept regenerative therapies and increase the likelihood of successful clinical outcomes and also discussed risks associated with modulating the immune system. This Proceedings of a Workshop highlights the presentations and discussions that occurred during the workshop.

DKK 266.00
1